Vitaly Smelov

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BACKGROUND Anal lymphogranuloma venereum (LGV) infections, caused by Chlamydia trachomatis biovar L (Ct+/LGV+), are endemic among men who have sex with men (MSM). Anal non-LGV biovar Ct infections (Ct+/LGV-) can be eradicated with 1 week doxycycline, whereas Ct+/LGV+ infections require 3-week doxycycline. To differentiate Ct+/LGV+ from Ct+/LGV- infections,(More)
BACKGROUND Human papillomavirus (HPV) genotyping using next generation sequencing (NGS) could be useful to study the HPV variant-specific epidemiology, including monitoring for possible emergence of new HPV variants after introduction of HPV vaccination programs. OBJECTIVES We wished to design and validate a method for rapid HPV detection, typing and(More)
INTRODUCTION Little is known about chlamydia survival in the presence of fluoroquinolones in patients with chronic prostatitis syndrome (CPS). In vitro activities of four fluoroquinolones, azithromycin and doxycycline against C. trachomatis in patients with CPS being not treated with antibiotics earlier were investigated and compared. MATERIAL AND METHODS(More)
Microbial cure of chlamydia proctitis (lymphogranuloma venereum [LGV] and non-LGV) with doxycycline treatment was evaluated by chlamydia DNA and RNA persistence in anal swab specimens. In LGV proctitis, RNA persisted for up to 16 days. In non-LGV chlamydia proctitis, DNA was undetectable after 7 days. These findings support the Centers for Disease Control(More)
OBJECTIVES To assess whether the increased sensitivity of screening for human papillomavirus (HPV) may represent overdiagnosis and to compare the long term duration of protective effect against cervical intraepithelial neoplasia grade 2 or worse (CIN2+) in HPV based and cytology based screening. DESIGN 13 year follow-up of the Swedescreen randomised(More)
OBJECTIVES Anal infection by cutaneous Human Papillomaviruses (HPV) has been rarely investigated. We aimed to assess the prevalence, genotype diversity, and determinants of mucosal (alpha) and cutaneous (beta and gamma) anal HPV infection in men who have sex with men (MSM). METHODS Anal samples were collected with a Dacron swab. Alpha HPVs were detected(More)
1. Urbanization; an increasing risk factor for leishmaniasis. Wkly Epidemiol Rec. 2002;44:365–72. 2. Abranches P, Lopes FJC, Conceição-Silva FM, Ribeiro MMS, Pires CA. Kala-azar in Portugal. III. Results of a survey on canine leishmaniasis performed in the Lisbon region. Comparison of urban and rural zones [in French]. Ann Parasitol Hum Comp.(More)
Recent reports on lymphogranuloma venereum (LGV) proctitis in men who have sex with men (MSM) have highlighted the fact that affordable diagnostic procedures for both symptomatic as well as asymptomatic LGV infections are urgently needed. 2 LGV responds well to extensive antibiotic treatment but when untreated, LGV can cause chronic or irreversible(More)
Human papillomavirus (HPV) infections result in a significant burden of low-grade cervical lesions. Between 1997 and 2000, our randomized trial of primary HPV screening enrolled 12,527 women participating in population-based screening. Women between 32 and 38 years of age (median: 34, interquartile range: 33-37) were randomized to HPV and cytology double(More)