Vitaly G. Dzhavakhiya

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A common consequence of using agricultural fungicides is the development of resistance by fungal pathogens, which undermines reliability of fungicidal effectiveness. A potentially new strategy to aid in overcoming or minimizing this problem is enhancement of pathogen sensitivity to fungicides, or "chemosensitization." Chemosensitization can be accomplished(More)
Ulocladols A and B — new exometabolites having a mixed sesquiterpenoid-polyketide nature that are structurally close to the host-specific toxins ofAlternaria citri — have been isolated from the deuteromyceteUlocladium chartarum. Both substances inhibit the growth of cotton seeds.
BACKGROUND Aflatoxin B1 (AFB1), produced by Aspergillus flavus, is one of the most life threatening food contaminants causing significant economic losses worldwide. Biological AFB1 degradation by microorganisms, or preferably microbial enzymes, is considered as one of the most promising approaches. OBJECTIVES The current work aimed to study the(More)
25 Mycotoxins—metabolites of microscopic mold fungi widely spread in nature—are the most hazard ous pollutants of agricultural raw materials and food stuff. They are highly toxic and cause severe intoxica tions in humans and animals; some of them are car cinogens. The stability of mycotoxins determines the necessity of stringent control of their content in(More)
Elicitors of biological origin, especially those that are able to control plant pathogens by induction of plant systemic resistance are being intensively investigated because of their great potential for crop protection and environmental compatibility. Since the range of induced defense responses can depend on the elicitor used, the plant treated and the(More)
Phytopathogenic fungi exhibit high resistance to extremal environmental conditions, which is largely determined by protective properties of high-molecularweight pigments of different composition contained in them. Melanin of cell walls of the pathogen Magnaporthe grisea that causes blast disease of rise is classified in the widespread type of pigments; it(More)
A polyketide exometabolite — 3,4,8-trihydroxy-3,4-dihydronaphthalen-1(2H)-one (3,4,8-TDH) — has been isolated from the culture liquids of four isolates of the phytopathogenic fungusPiricularia oryzae Cavara. It has been shown that all the natural isolates investigated, and also nonpathogenic rose mutants and a series of dwarf mutants synthesize 3,4,8-TDH.(More)
Aflatoxins and melanins are the products of a polyketide biosynthesis. In this study, the search of potential inhibitors of the aflatoxin B1 (AFB1) biosynthesis was performed among compounds blocking the pigmentation in fungi. Four compounds-three natural (thymol, 3-hydroxybenzaldehyde, compactin) and one synthetic (fluconazole)-were examined for their(More)
69 Development of resistance of pathogenic fungi to fungicides is a problem of general importance. Its solution requires not only intensification of the exist ing system of creation of fungicides, but also the necessity to develop new approaches to chemotherapy of fungal infections. In this regard, the search for methods to increase the sensitivity of(More)
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