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Identification of unique mechanisms for triterpene biosynthesis in Botryococcus braunii
TLDR
These findings were unexpected because squalene synthase, an ancient and likely progenitor to the other Botryococcus triterpene synthases, catalyzes a two-step reaction within a single enzyme unit without intermediate release, yet in B. braunii, these activities appear to have separated and evolved interdependently for specialized triterPene oil production greater than 500 MYA.
Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A.
TLDR
A family of fluorinated N,N-dialkylaminostilbene agents that inhibit the proliferation of CRC cells in vitro and in vivo are developed and suggest that FIDAS analogues targeting MAT2A represent a family of novel and potentially useful agents for cancer treatment.
Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression.
TLDR
F fluorinated N,N-dialkylaminostilbenes appear to inhibit Wnt signaling downstream of β-catenin, probably at the transcriptional level, and to develop more efficacious Wnt inhibitors than these natural products.
Synthesis and Characterization of Pseudocantharidins, Novel Phosphatase Modulators That Promote the Inclusion of Exon 7 into the SMN (Survival of Motoneuron) pre-mRNA*
TLDR
The data show that subtle changes in similar compounds can turn a phosphatase inhibitor into an activator, and chemically related compounds influence alternative splicing by distinct mechanisms.
Fluorinated N,N'-diarylureas as AMPK activators.
TLDR
A novel family of AMPK activators, namely fluorinated N,N'-diarylureas, that activate AMPK at 1-3μM concentrations are identified and strongly inhibit the proliferation of colon cancer cells.
Bis(N-amidinohydrazones) and N-(amidino)-N'-aryl-bishydrazones: New classes of antibacterial/antifungal agents.
TLDR
These studies show that bis(N-amidinohydrazones) and N-(amidino)-N'-aryl-bishydrazones are potentially promising scaffolds for the discovery of novel antibacterial and antifungal agents.
An Underlying Mechanism of Dual Wnt Inhibition and AMPK Activation: Mitochondrial Uncouplers Masquerading as Wnt Inhibitors.
TLDR
It is reported that several "Wnt inhibitors" that allegedly target β-catenin actually function as mitochondrial proton uncouplers that independently activate AMPK and concomitantly inhibit Wnt signaling.
Arylquins Target Vimentin to Trigger Par-4 Secretion for Tumor Cell Apoptosis
TLDR
A 3-arylquinoline derivative, designated Arylquin 1, is identified as a potent Par-4 secretagogue in cell cultures and mice and triggers the efficient paracrine apoptosis of diverse cancer cells.
2′,6′-Dihalostyrylanilines, Pyridines, and Pyrimidines for the Inhibition of the Catalytic Subunit of Methionine S-Adenosyltransferase-2
TLDR
Modifications led to FIDAS agents that were active in the low nanomolar range, that formed water-soluble hydrochloride salts, and that possessed the desired property of not inhibiting the human hERG potassium ion channel at concentrations at which the F IDAS agents inhibit MAT2A.
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