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ATG15 encodes a phospholipase and is transcriptionally regulated by YAP1 in Saccharomyces cerevisiae
TLDR
It is demonstrated that Atg15p is a phosphatidylserine lipase and that Yap1p activates the expression of ATG15 during autophagy, and that S. cerevisiae genome identified 13 proteins that contain a conserved, putative serine hydrolase motif. Expand
Functional analysis of the biochemical activity of mammalian phosphatidylinositol 5 phosphate 4-kinase enzymes
TLDR
It is found that all three mammalian PIP4K isoforms are able to enhance salivary gland cell size in the Drosophila PIP 4K null mutant implying a lack of correlation between in vitro activity measurements and in vivo function. Expand
Phosphatidylinositol 5 Phosphate 4-Kinase Regulates Plasma-Membrane PIP3 Turnover and Insulin Signaling
TLDR
PIP4Ks are key regulators of receptor tyrosine kinase signaling with implications for growth factor-dependent processes including tumor growth, T cell activation, and metabolism. Expand
Arabidopsis serine/threonine/tyrosine protein kinase phosphorylates oil body proteins that regulate oil content in the seeds
TLDR
The results provide the evidences thatArabidopsis At2G24360 (STYK) is phosphorylating oil body proteins and the phosphorylation regulates the oil content in Arabidopsis seeds. Expand
A novel mass assay to measure phosphatidylinositol-5-phosphate from cells and tissues
TLDR
A simple and reliable, non-radioactive mass assay to measure total PI5P levels from cells and tissues of Drosophila, a genetically tractable multicellular model, and captures and quantifies the unique acyl chain composition ofPI5P from Drosophile tissues. Expand
A novel mass assay to measure phosphatidylinositol-5-phosphate from cells and tissues
TLDR
The potential of the method to quantify PI5P levels with high sensitivity from cells and tissues of multicellular organisms thus accelerating understanding ofPI5P functions in vivo is demonstrated. Expand