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RNAi pathway is functional in peripheral nerve axons
Recent observations demonstrated that translation of mRNAs may occur in axonal processes at sites that are long distances away from the neuronal perikaria. While axonal protein synthesis has beenExpand
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Cardiac myofibroblasts: a novel source of vascular endothelial growth factor (VEGF) and its receptors Flt-1 and KDR.
Vascular endothelial growth factor (VEGF), produced predominantly by endothelial cells, is involved in angiogenesis and mitogenesis. Myofibroblasts (myoFb) are phenotypically transformedExpand
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Role of protein kinase C-delta in angiotensin II induced cardiac fibrosis.
Previous studies have demonstrated a role for angiotensin II (AngII) and myofibroblasts (myoFb) in cardiac fibrosis. However, the role of PKC-delta in AngII mediated cardiac fibrosis is unclear.Expand
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PPAR-gamma agonists induce the expression of VEGF and its receptors in cultured cardiac myofibroblasts.
OBJECTIVES Myofibroblasts (myoFb) are the major cell types that appear at the site of myocardial infarction (MI) in response to injury and play a vital role in tissue repair/remodeling. SinceExpand
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Identification, cloning and functional characterization of novel beta-defensins in the rat (Rattus norvegicus)
Backgroundbeta-defensins are small cationic peptides that exhibit broad spectrum antimicrobial properties. The majority of beta-defensins identified in humans are predominantly expressed in the maleExpand
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Induction of VEGF and its Flt-1 receptor after sciatic nerve crush injury
Expression of vascular endothelial growth factor and its receptors Flt-1 and Flk-1 was studied in lumbar spinal cord after sciatic nerve crush injury. Immunohistochemical staining revealed strikinglyExpand
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MicroRNA-9 is an activation-induced regulator of PDGFR-beta expression in cardiomyocytes.
The platelet derived growth factor receptor (PDGFR) is an important target for novel anti-cancer therapeutics, but agents targeting PDGFR have been associated with cardiotoxicity. CardiomyocyteExpand
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Role of Protein Kinase Cδ in Endothelin-Induced Type I Collagen Expression in Cardiac Myofibroblasts Isolated from the Site of Myocardial Infarction
The role of endothelin-1 (ET) in tissue remodeling/fibrogenesis has been demonstrated in various in vitro and in vivo models. Our previous studies have revealed ET-induced expression of type IExpand
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Differential expression of endothelin receptors in regenerating spinal motor neurons in mice.
On day 4 after sciatic nerve crush injury, expression and localization of endothelin receptors ET(A) and ET(B) in the lumbar spinal cord were examined. Immunohistochemical staining with antibodies toExpand
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