Vishal Kishore

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All of the steroidal anti-inflammatory drugs currently available are glucocorticoids. They exhibit both glycogenic and anti-inflammatory activities. These two activities are usually considered inseparable. This glycogenic activity is responsible for most of the adverse side effects that severely limit clinical use of currently available steroidal(More)
  • V Kishore
  • 1989
In a study on the effects of adjuvant arthritis on copper (Cu), zinc (Zn), and iron (Fe) metabolism in the rat, most significant changes were observed in the liver and pancreas where arthritis caused a large increase in the concentrations of all three metals. Results also indicated that although arthritis-induced changes in metal concentrations were highly(More)
Both severe and marginal copper deficiency were produced in male Sprague Dawley rats prior to induction of adjuvant arthritis. Degree of copper deficiency was confirmed by analysis of plasma, liver, and brain samples prior to adjuvant injection. Incidence of adjuvant arthritis was the same in both copper deficient and control animals although the severity(More)
Copper complexes have been shown to be effective antiinflammatory, antiulcer, anticonvulsant, anticancer, and antidiabetic agents. This seemingly diverse variety of pharmacologic effects is unified by the hypothesis that copper complexes facilitate or promote tissue repair processes involving copper-dependent enzymes and that arthritis, ulcers, seizures,(More)
A 14- year-old boy presented at the outpatients' department with the complaint of visual loss in the right eye of 1 1/2 months duration. He had the history of snakebite for which he was admitted to hospital. The diminution of vision started next day after snakebite. On examination, he had no perception of light in his right eye. USG B scan showed vitreous(More)
  • V Kishore
  • 1990
Concentrations of copper, zinc, and iron were analyzed and compared in a number of tissues of adjuvant arthritic rats following 22 d of chronic treatment (per os) with either vehicle, aspirin or copper aspirinate, at doses of 100 mg/kg, 200 mg/kg, or 400 mg/kg. Such chronic treatment resulted in a negative balance in copper, zinc, and iron in many tissues.(More)
Eight 1-(naphth-1-ylacetyl)-4-substituted thiosemicarbazides and eight 2-(naphth-1-ylmethyl)-5-arylamino-1,3,4-oxadiazoles were synthesized and evaluated for antiinflammatory and antiproteolytic properties. All thiosemicarbazides (100 mg/kg) provided 14-43% protection against carrageenin-induced edema in rats. Cyclization of thiosemicarbazides to(More)
Ten N-(4-propoxyphenyl)-N'-(4-chlorophenethyl)-N"-substituted guanidines were synthesized from the corresponding 1-(4-propoxyphenyl)-3-substituted thiocarbamides and evaluated for anti-inflammatory and antiproteolytic properties. All substituted guanidines (50 mg/kg) provided 1-31% protection against carrageenin-induced edema in rats. Hydrocortisone (10(More)
This study was undertaken to determine if progesterone is secreted in response to an adjuvant-induced arthritis challenge in the rat. While the arthritic rat paw volume increased 33%, the plasma progesterone concentration increased from 502 pg/ml in the control rats to 1,202 pg/ml in the arthritic animals. A strong positive correlation was found between the(More)