Virginia A. Clark

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The progression of prostate carcinoma may be influenced by the biochemical nature of the basal lamina surrounding the primary carcinoma cells. As a first step toward understanding this process, the composition and structure of the basal lamina in normal prostate, prostatic intraepithelial neoplasia, and human carcinoma were determined. In addition, a(More)
The epithelial basal lamina composition and integrin expression profile of normal and neoplastic human prostate was characterized using immunohistochemical analysis of frozen samples. The major components of the basal lamina surrounding normal acini were laminin, type IV collagen, entactin, and type VII collagen with variable amounts of tenascin. The basal(More)
The occurrence of depression was determined during the summer of 1979 in a multi-ethnic probability sample of 1003 adults (66% participation) in Los Angeles County, as part of a community survey of the epidemiology of depression and help-seeking behavior. The primary measure of depression was the 20-item CES-D scale developed by the Center for Epidemiologic(More)
A cohort of 886 cases of multiple sclerosis (MS) who had onset between Jan 1, 1960, and Dec 31, 1969, and who were resident in 1970 in either a low-prevalence area (Los Angeles County, California, 560 cases) or in a high-prevalence area (King and Pierce Counties, Washington, 326 cases) were followed up for changes in disability status through Dec 31, 1979.(More)
Two murine monoclonal anti-cytokeratin antibodies with defined specificity were shown to distinguish between basal cells and luminal cells in human prostate tissue. Forty-one biopsies or transurethral resection specimens were characterized using these two antibodies. In cases of benign prostatic hyperplasia, focal loss of the basal cell layer was noted in(More)
Interview method effects in response to the Center for Epidemiologic Studies-Depression Scale (CES-D) are compared among a community sample (N = 546) of adults randomly assigned to either telephone or in-person interviews. The interviews were conducted in Los Angeles during 1980. No significant differences were observed between the two interview methods in(More)
Thirty-one snap-frozen human prostate specimens containing examples of benign hyperplasia, prostatic intraepithelial neoplasia (PIN), and invasive carcinoma were analyzed using a panel of 24 antibodies and one lectin. Twenty-seven additional routinely processed radical prostatectomy specimens were studied using selected probes known to work on(More)
This study addresses two questions: (a) Are depressive-symptom scales equally indicative of depression in different racial/ethnic groups and (b) are there mean differences between the groups in the underlying depressive disorder assessed by these scales? The data consist of interviews obtained from a large community survey of depression in Los Angeles(More)
The effects of zinc supplementation on levels of various blood constituents and the outcome of pregnancy in 213 Hispanic women attending a prenatal clinic in Los Angeles was assessed in this double-blind study. The women were randomized into either a control (C) or a zinc-supplemented (Z) group and received similar vitamin and mineral supplements except(More)