Virgina Clark

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BACKGROUND Standard of practice involves using transarterial therapy for multifocal hepatocellular carcinoma (HCC) alone and sorafenib only for more advanced HCC, but the sorafenib and transarterial therapy combination may provide greater efficacy. AIM To evaluate the safety and efficacy of concurrent sorafenib and transarterial therapy in HCC. METHODS(More)
e14598 Background: Treatment with sorafenib (S) is reserved for advanced, unresectable hepatocellular carcinoma (HCC) but may provide greater efficacy when combined with transarterial therpay (T) in earlier disease. AIM Because limited data exist on the T+S combination, this study evaluated the safety and tolerability of this combination in a series of(More)
BACKGROUND AND AIMS Information about the natural history of small duct primary sclerosing cholangitis (SDPSC) remains scant despite literature suggesting that it constitutes 6-16% of all cases of primary sclerosing cholangitis (PSC). We combined clinical data on SDPSC cases from two tertiary care institutions with liver transplantation programs with the(More)
OBJECTIVES To evaluate the impact of long-term outcomes of transarterial embolization (TAE) therapy in patients with hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) on the waiting list for liver transplantation (LT). METHODS We retrospectively evaluated the post-LT patients with HCV-related HCC who received TAE intervention (n=33) and those(More)
OBJECTIVE Many approaches for minimally invasive heart surgery are available. Although they have many advantages, inadequate exposure, mammary artery injury and special tool requirements are known problems. Subtotal median sternotomy (SMS) was developed to overcome such limitations. Comparing the SMS with the standard sternotomy (SS) is the purpose of this(More)
OBJECTIVE There is a paucity of data regarding the optimal form of bowel preparation for flexible sigmoidoscopy. Most endoscopists recommend enemas. A simpler preparation that is easy, acceptable, and that reduces patient encounter time would be desirable, and might be cost-effective. Our objective in this study was to evaluate a simple oral form of(More)
OBJECTIVES To determine whether restarting of Beta Blocker following cardiac surgery would reduce the incidence and the severity of post-operative atrial fibrillation (AF). METHODS 210 patients who underwent elective coronary artery bypass grafting were randomized to control (C) (n = 105) and Beta Blockers (BB) (n = 105) groups. Preoperatively all(More)
BACKGROUND Newer therapies are needed for patients with primary biliary cirrhosis and incomplete response to ursodeoxycholic acid (UDCA). Fenofibrate is a fibric acid postulated to regulate immune response and cell proliferation. AIM To evaluate the efficacy and safety of fenofibrate in patients with primary biliary cirrhosis and incomplete response to(More)
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