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EM-652 (SCH 57068), a third generation SERM acting as pure antiestrogen in the mammary gland and endometrium
EM-652 was the most potent antiestrogen to inhibit the growth of human breast cancer ZR-75-1, MCF-7 and T-47D cells in vitro when compared with ICI 182780, ICI 164384 and EM-800, the prodrug of EM-652, has been shown to prevent the development of dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma in the rat. Expand
Prevention of bone loss by EM-800 and raloxifene in the ovariectomized rat
The present data show the potent effect of EM-800 preventing bone loss and lower serum cholesterol levels without the negative effect on the endometrium, thus suggesting the particular interest of this new fully tissue-specific selective estrogen receptor modulator. Expand
A Toxicogenomic Approach for the Prediction of Murine Hepatocarcinogenesis Using Ensemble Feature Selection
This study investigated a novel method for the evaluation of toxicogenomics data based on ensemble feature selection in conjunction with bootstrapping for the purpose to derive reproducible and characteristic multi-gene signatures and developed predictive models based on gene expression data of both sexes. Expand
Comparison of rat and human responses to toll-like receptor 7 activation.
It is concluded that rat and human cells respond differently toTLR7 activation and that these differences should be considered when using rat as a model to study TLR7 agonists. Expand