Violetta Dymicka-Piekarska

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BACKGROUND Platelets are an important element in the thrombotic process, inflammation and cancer progression. We tested the hypothesis that there is a relationship between platelet activation and inflammation in colorectal cancer patients (CRC). PATIENTS/METHODS We measured soluble (s) P-selectin (marker of platelet activation), interleukin-6 (IL-6) and(More)
Adhesion molecules take part in physiological and pathological processes. They involved in inflammatory reactions and play important role in tumor invasion and the development of metastases. Soluble forms of P-selectin, E-selectin and ICAM-1 have been described in this study in patient with colorectal cancer. Plasma was obtained from 44 patients with(More)
INTRODUCTION Adhesion molecules take part in the interaction between host cells and cancer cells. In the current study the relationship between the soluble adhesion molecules sICAM-1 and sVCAM-1 and proangiogenic factor VEGF in colorectal cancer progression were measured. MATERIALS AND METHODS The study group consisted of 46 patients with colorectal(More)
UNLABELLED Gender-dependent differences in platelet count have been demonstrated in few studies. In women platelet count is higher than in men, which seems to reflect different hormonal profiles or a compensatory mechanism associated with menstrual blood loss. The aim of the study was to assess platelet count, mean platelet volume and thrombocytopoietic(More)
The study objective was to determine the presence of MMP-7 in cancer tissue in correlation with its serum level in patients diagnosed with colorectal cancer (CRC). In 45 patients with CRC, MMP-7 expression was assessed immunohistochemically on FFPE slides in tumours (N = 37) and in the corresponding surgical margin sample. MMP-7 serum level was measured(More)
In the study performed in a group of patients infected with T. gondii, we evaluated Th2 humoral response (IL-5, IL-6, IL-10) and Th1 cell response (IL-12, TNF-alpha). The study objective was to assess the effect of T. gondii on chosen indices of the immune response. The study involved 52 women infected with T. gondii (aged 18-42 years) prior to(More)
The objective of the current study was to assess the expression of matrix metalloproteinase 9 (MMP-9) in pancreatic ductal carcinoma and to examine its correlation with chosen clinico-anatomical parameters. The study group consisted of 36 patients with pancreatic ductal carcinoma. Tumors were stained using immunohistochemical method (NCL -MMP-9,(More)
The immune system, its cellular and humoral response, is engaged by the host organism to fight against parasitic infections. The study group consisted of 90 patients (58 women and 32 men), aged 18-72 years, infected with G. intestinalis. The diagnosis was established based on laboratory investigations (stool examination, choloscopy, GSA-65). Blood for(More)
BACKGROUND Atheromatous plaque rupture is the main cause of platelet activation in ischaemic heart disease (IHD). Platelet activation is manifested by a release into circulation of the components of granules, including beta-thromboglobulin (beta-TG) - a marker of platelet activation in vivo. The platelet count (PLT), mean platelet volume (MPV) and the(More)
UNLABELLED Platelet activation as a result of atheromatous plaque rupture in ischaemic heart disease can be detected by assesses plasma concentration of beta-thromboglobulin (beta-TG) and indirectly by changes in platelet counts (PLT). At the same time myocardial ischaemia and local destruction of cardiomyocyte leads to the increase troponin I(More)