Violeta Vladimirova

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OBJECTIVE The aim of this study was to clarify the relationship between morphologic changes of the pituitary gland and the genotype of Prophet of Pit-1 (PROP1), a newly discovered gene responsible for congenital combined pituitary hormone deficiency, in a series of eight humans with this disorder. CONCLUSION Congenital hypoplasia of the anterior pituitary(More)
The authors considered 3 variants of radiation therapy of esophageal cancer using megavoltage radiation sources: standard methods including a continuous course, optimized planning including a continuous and split irradiation course. In the use of megavoltage sources and a continuous irradiation course the 5-year survival was 8.8%. The use of a split course(More)
The study was concerned with morphologic examination of resected esophagi from patients operated on for esophageal cancer at various intervals after radiotherapy with a total dose of 40-50 Gy. A correlation was established between the level of tumor destruction and duration of the interval between the said procedures of treatment. The results of the study(More)
A group of 42 cystic fibrosis (CF) patients and 80 heterozygote carriers was analysed for determining the prevalent CF haplotypes and the frequency of ΔF508. The “high-risk” haplotype B (XV2c-KM19/1 2) was found in 66% of CF chromosomes. The prevalent normal haplotypes were A (1 1) and B (2 1). The deletion was detected in 54 CF chromosomes (56%),(More)
A comparative estimation is given of the results of radiotherapy in 85 patients with cancer of the true vocal cords in stage T1--2N0M0 depending on focal dosage in rad and ret units. There was noted a distinct correlation between the results of the treatment and the dosage applied. The immediate clinical cure was gained in 88.2% of cases. In this group of(More)
BACKGROUND AND AIMS In critically ill patients, fractional hepatic de novo lipogenesis increases in proportion to carbohydrate administration during isoenergetic nutrition. In this study, we sought to determine whether this increase may be the consequence of continuous enteral nutrition and bed rest. We, therefore, measured fractional hepatic de novo(More)
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