Violeta Millan

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UNLABELLED After a single IV injection of the water-soluble propofol prodrug propofol phosphate (PP) in mice, rats, rabbits, and pigs, propofol was produced rapidly (1-15 min), inducing dose-dependent sedative effects. In mice, the hypnotic dose (HD(50)), lethal dose (LD(50)), and safety index (defined as a ratio: LD(50)/HD(50)) were 165.4 mg/kg, 600.6(More)
Percutaneous transluminal renal angioplasty (PTRA) was performed in a group of 12 patients with marked renal functional impairment, severe hypertension, and critical renovascular stenoses in a solitary functioning kidney (ten patients) or bilaterally (two patients). The procedure led to least partial dilation in 11 of the 13 stenoses acted on and(More)
Percutaneous transluminal renal angioplasty (P.T.R.A.) was performed in a 43-year-old woman with medial fibroplasia of the right main renal artery that was causing high-grade stenoses and severe hypertension. The procedure led to a virtually complete dilatation of the stenosing lesions and a prompt and lasting fall in blood-pressure to normal.(More)
One hundred and two patients, presenting at the outpatient departments of two Boston teaching hospitals, underwent clinical examination and venography. History, physical examination and presence of risk factors were unreliable in the diagnosis of deep venous thrombosis. Seventy-two per cent of the patients with deep venous thrombosis had a proximal(More)
The long-term effect of percutaneous transluminal renal angioplasty (PTRA) on blood pressure and renal function was assessed in 100 consecutive patients with atherosclerotic renovascular hypertension. Technical success rates (complete plus partial) of a first PTRA averaged 76.2%, 74.1%, and 67.7% for the unilateral (n = 42), bilateral (n = 27), and solitary(More)
Nineteen stenotic arteries in 16 patients with severe renovascular hypertension of nonatherosclerotic nature (fibromuscular dysplasia in 13, neurofibromatosis in 3) were treated with percutaneous transluminal renal angioplasty. The procedure was technically successful in 12 of 14 (86%) stenoses in the fibromuscular dysplasia subgroup but in only one of five(More)
Thirteen patients with severe, unilateral, atherosclerotic renovascular hypertension were treated with percutaneous transluminal renal angioplasty. The procedure produced wide patency of the stenosed vessel in 10 patients and partial dilatation in the remaining three. All patients exhibited a beneficial response in their hypertension; at latest follow-up,(More)