Violeta M. Ivanova

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After oxidation of the catalytically active sulfhydryl group of Cys-149, glyceraldehyde-3 phosphate dehydrogenase is known to acquire an acylphosphatase activity. Modification of one cysteine residue, obviously Cys-153, with p-mercuribenzoate or N-ethylmaleimide fully inactivates the phosphatase activity of the oxidized enzyme suggesting that this amino(More)
The immune-enzyme system of testing was developed to detect the level of Ca2+ ATPase of sarcoplasmic reticulum using monoclonal IgM and IgG antibodies to Ca2+ ATPase. The clinical approbation of the technique was carried out using the sample of 19 patients with acute cardiac infarction Q validated by the increase of content of such common markers of(More)
A study was made of the blastomogenic activity of dioxydin, a new antibacterial broad-action drug. Administration of dioxydin in doses of 20-100 mg/kg (exceeding 2-10-fold the therapeutic dose for humans) to mice and rats intragastrically for 18 months and intraperitoneally (2 years of observation) as well as combined administration of the drug to rats(More)
Oxygen consumption was compared during phagocytosis of killed S. aureus by peritoneal polymorphonuclear leukocytes (PNL) from conventional mice and C57BL/6 mice free of pathogenic agents. The rate of oxygen consumption by PNL during phagocytosis was 3 times higher in conventional mice than in C57BL/6 mice free of pathogenic agents. The latter mice can be(More)
The effects of dispirotripiperazine derivatives spirobromin and prospidin on the parameters of the peripheral blood and behavioral reactions in a chronic 12-month experiment were studied. The experiment was performed on noninbred rats of both sexes. The maximal tolerated doses of the drugs were administered by two routes (intragastrically or(More)