Vinzens Hombach

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The whole-cell recording technique was used to register Na+ currents from 403 atrial cardiocytes isolated from 80 human biopsies. With intracellular [Na+] ([Na+]i) raised to 70 mM, and at physiological extracellular [Na+] ([Na+]e, 145 mM) and room temperature, the Na+ currents were small enough for the error of the voltage clamp not to exceed 2 mV (series(More)
Aim of this study was to evaluate quantitative parameters for inter-and intra-ventricular dyssynchronicity measurement. 10 patients with severely reduced left ventricular function (LVF) and variable QRS duration (70% had left bundle branch blockation; LBBB) and six healthy subjects (control) were examined with cine magnetic resonance imaging. The phase(More)
A new method for automatically detecting left ventric-ular endocardial borders in cardiac MRI short-axis slices was applied to a previously published patient group [1] for which manually drawn contours already existed. An initial point lying in the left ventricular endocardium was found by a size invariant circular Hough transform. A coarse segmentation of(More)
The patch-clamp technique was used to examine the presence of large conductance calcium-activated potassium channels (BKCa) in human endothelial cells and to characterize their properties in terms of voltage dependence, ion conduction and blockade by iberiotoxin (IbTX). Experiments were performed using cell-attached and outside-out configurations on human(More)
Patients with idopathic dilated cardimyopathy (IDC) and reduced left ventricular function have a limited prognosis. Aim of this study was the evaluation of parameters of cardiac magnetic resonance imaging (CMRI) and ECG for prognosis. 149 patients with IDC were studied by CMRI for hemodynamic and late enhancement (LE) analysis and followed for a mean of 986(More)
A robust model-based segmentation method for automatically detecting left ventricular endocardial borders in cardiac MRI short-axis slices is proposed. The method is evaluated with expert drawn contours on an extended dataset (83 cases). The contour detection involves the four steps: (a) A region of interest enclosing the left ventricle is computed using a(More)
Modelling the electromagnetic properties of the thorax in magnetocardiographic (MCG) studies is usually performed by the Boundary Element Method (BEM). Magnetic Resonance Imaging (MRI) scans are generally used as the basis for extracting the coordinates for BEM. As MRI is a (time) expensive technique and scanners have a high use demand, in this work a(More)
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