Vinod Kumar Singh

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Parkinson's disease (PD) is a progressive neurodegenerative disorder, characterized by the selective loss of dopaminergic neurons of the nigrostriatal pathway. Epidemiological studies have shown an inverse relationship between coffee consumption and susceptibility to PD. Cytochrome P450 1A2 (CYP1A2) is involved in caffeine metabolism and its clearance.(More)
The main contributory factors of Parkinson's disease (PD) are aging, genetic factors, and environmental exposure to pesticides and heavy metals. CYP2D22, a mouse ortholog of human CYP2D6, is expected to participate in a chemically induced PD phenotype due to its structural resemblance with CYP2D6. Despite its expected participation in PD, its expression in(More)
We report the first complete genome sequence of a classical swine fever (CSF) virus of subgenotype 2.2. The virus (CSFV/IND/UK/LAL-290) was isolated from the Uttarakhand state of India from a backyard pig suspected of having CSF. This genome sequence will give useful insight for future molecular epidemiological studies and the development of an effective(More)
BACKGROUND Ophthalmic drug delivery systems are the challenging subject for the researchers because of delicate nature of ocular membrane and preventive barriers leading to less than 1 % of Bioavailability. Reasons for reduced bioavailability are due to rapid pre corneal elimination, tear turnover, lacrimal drainage, blinking and degradation by enzymes.(More)
BACKGROUND Stimuli-sensitive hydrogels are three-dimensional, hydrophilic, polymeric networks capable of imbibing large amounts of water or biological fluids on stimulation, such as pH, temperature and ionic change. AIM To develop hydrogels that are sensitive to stimuli, i.e. pH, in the cul-de-sac of the eye for providing a prolonged effect and increased(More)
Widespread nutrient deficiencies have emerged as the major soil-related constraints, with sulfur (S) being one among them, for sustaining rice–wheat productivity in many parts of the north-western Indo-Gangetic Plain (IGP) and the Western Himalayan region (WHR). Therefore, soils from different agricultural development blocks (ADBs) of Meerut and Jyotiba(More)
High fertilizer use efficiency in rice (Oryza sativa L.)-based cropping systems in Indo-Gangetic Plains (IGP) is not achieved because farmers’ fertilizer practices (FFP) and blanket state recommendations (BSR) do not take into account the site-specific variability of nutrient availability in the soil. We evaluated the site-specific nutrient management(More)
Bioavailability is defined as the rate and extent (amount) of absorption of unchanged drug from its dosage form. It is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response to be shown. A drug with poor bioavailability is one with poor aqueous solubility, slow dissolution rate in(More)
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