Vinod Krishnan

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Remodeling changes in paradental tissues are considered essential in effecting orthodontic tooth movement. The force-induced tissue strain produces local alterations in vascularity, as well as cellular and extracellular matrix reorganization, leading to the synthesis and release of various neurotransmitters, cytokines, growth factors, colony-stimulating(More)
Orthodontic pain, the most cited negative effect arising from orthodontic force application, is a major concern for parents, patients, and clinicians. Studies have reported this reaction to be a major deterrent to orthodontic treatment and an important reason for discontinuing treatment. Surprisingly this area, which requires attention in clinical practice(More)
Recent developments in material science have presented newer archwire materials as well as improvements in the properties of existing ones. Proper selection and understanding of the biomechanical requirement of each case requires proper characterization studies on archwire alloys. The present study characterizes and compares three orthodontic archwire(More)
Algorithmic recommender systems attempt to predict which items a target user will like based on information about the user's prior preferences and the preferences of a larger community. After more than a decade of widespread use, researchers and system users still debate whether such "impersonal" recommender systems actually perform as well as human(More)
Orthodontic forces deform the extracellular matrix and activate cells of the paradental tissues, facilitating tooth movement. Discoveries in mechanobiology have illuminated sequential cellular and molecular events, such as signal generation and transduction, cytoskeletal re-organization, gene expression, differentiation, proliferation, synthesis and(More)
INTRODUCTION Smile evaluation and designing are important; recent emphasis on the soft tissues has been on par with that on the hard tissues in orthodontic diagnosis and treatment planning. This importance has not yet gained proper attention, and smile analysis is often ignored in clinical examinations. We attempted a comprehensive evaluation of smile(More)
OBJECTIVE Molecules produced in various diseased tissues, or drugs and nutrients consumed regularly by patients, can reach the mechanically stressed paradental tissues through the circulation, and interact with local target cells. The combined effect of mechanical forces and one or more of these agents may be inhibitory, additive or synergistic. The(More)
Whether to treat hyperuricemia uncomplicated by articular gout, urolithiasis, or uric acid nephropathy is an exercise in clinical judgment and universal agreement is lacking. Patients with coronary artery disease, chronic kidney disease, and early onset hypertension with persistent hyperuricemia are likely to be benefited with urate-lowering therapy. The(More)
Adverse effects are results beyond the expected good outcomes of treatment. Like any other field in dentistry and medicine, orthodontics is not immune to such effects. The probability of adverse results in orthodontics increases when important rules and facts are ignored. To illustrate this, treatment and its adverse effects in 2 patients are discussed. In(More)
Root resorption, an unwanted sequela of orthodontic treatment, has received much attention in the recent past. This is clearly evident from the enormous amount of literature published regarding this single iatrogenic issue. These research works should provide practitioners with great insight into the clinical, histologic, therapeutic, predictive, and(More)