Vinny Monaco

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Trichogin GA IV is a lipopeptaibol antibiotic characterized by the sequence nOct-Aib1-Gly-Leu-Aib4-Gly-Gly-Leu-Aib8-Gly-Ile- Lol (nOct: n-octanoyl; Aib: alpha-aminoisobutyric acid; Lol, leucinol), which exhibits membrane-modifying properties. We synthesized step-by-step by solution methods three trichogin analogues, each with a single Aib -->(More)
Trichogin GA IV is a 11-residue lipopeptaibol antibiotic exhibiting membrane modifying properties. We synthesized step-by-step by solution methods three trichogin analogues, each with a double Aib (alpha-aminoisobutyric acid)-->TOAC (2,2,6,6-tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid) replacement. The strict similarity in the conformational(More)
In continuation of our studies on the structure and function of peptaibol antibiotics, the conformational properties of a sequence analogous to that of Trichodecenin I (Z-Gly-Gly-D-Leu-Aib-Gly-D-Ile-D-Leu-OMe, where Z = benzyloxycarbonyl, Aib = alpha-aminoisobutyric acid, and OMe = methyl ester) have been investigated crystallographically. This sequence is(More)
The step-by-step synthesis by solution methods of the [Ser2,5,6,9, Leu-OMe11] analog of trichogin GA IV is described. The four Ser residues have been incorporated into the sequence as replacements of the naturally occurring Gly residues to increase the amphiphilicity of the 3D-structure of the lipopeptaibol. A detailed solution conformational analysis has(More)
Objective This study's objective was to formally describe the work process for charting and treatment planning in general dental practice to inform the design of a new clinical computing environment.Methods Using a process called contextual inquiry, researchers observed 23 comprehensive examination and treatment planning sessions during 14 visits to 12(More)
We have synthesized by solution-phase methods two analogues of the 11-residue lipopeptaibol antibiotic trichogin GA IV in which the N-terminal n-octanoyl group is replaced either by an N-acetylated 2-amino-2-methyl-L-undecanoic acid or by an N-acetylated alpha-aminoisobutyric acid. CD, FTIR absorption. and NMR analyses unequivocally show that the main(More)
(Z)-Aib-Gly-L-Ile-L-Leu-OMe.H2O, C27H42N4O7.H2O, is a protected analogue of the C-terminal sequence of the membrane-active peptaibol antibiotic trichogin A IV. The peptide backbone is folded. The urethane carbonyl O atom acts as the acceptor of two intramolecular hydrogen bonds which give rise to a beta bend and to an alpha bend. The geometry of the latter(More)
The interaction of the antimicrobial peptide trichogin GA IV with phospholipid bilayers has been studied. A series of analogs of trichogin was synthesized in which the nitroxide spin label, 4-amino-4-carboxy-2,2,6,6-tetramethylpiperidino-1-oxyl (TOAC), replaced one of the three alpha-aminoisobutyric acid (Aib) residues in the sequence. These modified(More)
Some high-level biometric systems combine, or fuse, several biometrics to increase performance over that of an individual biometric system. This project will investigate how to combine, at the classification output level, several biometric systems, such as the various systems being developed in the Android Biometric System project, the Pace University(More)
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