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PURPOSE To determine whether keratoconus (KC) corneas have more mitochondrial (mt)DNA damage than do normal corneas. METHODS Thirty-three normal corneas and 34 KC corneas were studied. Immunohistochemistry for mitochondria-encoded cytochrome c oxidase (complex IV) subunit 1 (CO-Iota) and porins was performed. Total DNA was isolated and mtDNA genome(More)
PURPOSE To determine whether keratoconus (KC) corneal fibroblast cultures have increased reactive oxygen species (ROS) production and are more susceptible to stress-related challenges. METHODS Normal (n = 9) and KC (n = 10) stromal fibroblast cultures were incubated in either neutral- or low-pH conditions, with or without hydrogen peroxide. Catalase(More)
In this installation of architectural perspectives, we describe an extension of a menu-based natural language interface (MBNLI) to support geospatial queries. Our extension makes it easier for application analysts and even inexperienced users to phrase complex queries without knowing the relational database query language SQL, database schemas (table(More)
Eosinophilic esophagitis (EoE) is a clinicopathological condition characterized by the combination of upper gastrointestinal symptoms such as dysphagia and even food impaction in association with histological findings of >15 eosinophils/high-powered field found in endoscopic biopsy specimens. EoE is considered an atopic disease with food and aeroallergen(More)
I n this installation of Architectural Perspectives, we describe an extension of a menu-based natural language interface (MBNLI) to support geospatial queries. Our extension makes it easier for application analysts and even inexperienced users to phrase complex queries without knowing the relational database query language SQL, database schemas (table(More)
Chronic pruritic dermatitis with or without accompanying peripheral eosinophilia can be caused by a vast array of underlying disorders broadly classified as allergic/immunologic, infectious, or neoplastic. An organized and thorough work up is crucial in order to arrive at a definitive diagnosis enabling appropriate treatment. We present the case of a(More)
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