Vineet Hingorani

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The metabolism of norgestrel by the human endometrium and myometrium in vitro was investigated. These tissues metabolized norgestrel to 13beta-ethyl,17alpha-ethynl-5beta-estrane,3alpha,17beta-diol, 13beta-ethyl,17alpha-ethynyl-5beta-estrane,3beta,17beta-diol, and to some unidentified polar compounds which suggests that the enzyme 3-ketosteroid reductase(More)
Rabbit cerebral microvessels were used to study fatty acid metabolism and its utilization relative to glucose. Microvessels were incubated with either [6-14C]glucose or [1-14C]oleic acid and the incorporation of radioactivity into 14CO2, lactate, triglyceride, cholesterol ester, and phospholipid was determined. The inclusion of 5.5 mM glucose in the(More)
The immunogenicity of the conjugate prepared from "processed" beta-subunit of human chorionic gonadotropin (choriogonadotropin, HCG) and tetanus toxoid has been studied in animals and a human subject. The conjugate elicited the formation of high-affinity (Ka = 10(9)-10(11) M-1) anti-HCG and anti-tetanus antibodies. On primary immunization, the antibody,(More)
2 populations attending WHO centers, one in Sweden and one in India, participated in a comparative, pilot trial of 2 increasingly popular injectable progestin-only female contraceptives, Depo-Provera and Norigest. The purpose of the study was to assess the pharmacokinetic and pharmacodynamic properties of the 2 formulations (depot medroxyprogesterone(More)
A study has been done to assess the extent to which toxoplasma was responsible for fetal wastage. Hemagglutination and intradermal tests were used for diagnosis of toxoplasmosis. In addition, on 50 specimens of abortus material, placenta, and endometrial biopsy, animal innoculation was performed and at least 8 passages were done before negative results(More)
Interacting with computers is a ubiquitous activity for millions of people. Repetitive or specialized tasks often require creation of small, often one-off, programs. End-users struggle with learning and using the myriad of domain-specific languages (DSLs) to effectively accomplish these tasks. We present a general framework for constructing program(More)
Clinical profile and toxicology studies on 4 women immunized with processed beta human chorionic gonadotropin conjugated to tetanus toxoid (Pr-beta-HCG-TT) are presented. The women responded to active isoimmunization by production of anti-hcg and anti-TT antibodies. The women were followed for 1 year with monthly clinical examinations including laboratory(More)
Menstrual data of 13 control subjects and 88 subjects immunized with three beta-hCG-based vaccine formulations were analysed. Immunization did not change the menstrual regularity; bleeding days were normal (3-7 days) and 89% of the menstrual cycles were within the normal range of 22-35 days. Irregular (short or long) cycles were observed in both immunized(More)