Marco Iannetta8
Giancarlo Ceccarelli7
Miriam Lichtner7
Ilaria Sauzullo7
Alessandra Oliva6
8Marco Iannetta
7Giancarlo Ceccarelli
7Miriam Lichtner
7Ilaria Sauzullo
6Alessandra Oliva
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Chronic hepatitis C virus (HCV) infection is an important cause of morbidity and mortality in people coinfected with human immunodeficiency virus (HIV). Several studies have shown that HIV infection promotes accelerated HCV hepatic fibrosis progression, even with HIV replication under full antiretroviral control. The pathogenesis of accelerated hepatic(More)
  • Delia Goletti, Carrara Stefania, Ornella Butera, Massimo Amicosante, Martin Ernst, Ilaria Sauzullo +15 others
  • 2008
BACKGROUND The clinical application of IFN-gamma release assays (IGRAs) has recently improved the diagnosis of latent tuberculosis infection. In a multicenter study of the Tuberculosis Network European Trialsgroup (TBNET) we aimed to ascertain in routine clinical practice the accuracy of a novel assay using selected peptides encoded in the mycobacterial(More)
  • Ilaria Sauzullo, Fabio Mengoni, Miriam Lichtner, Anna Paola Massetti, Raffaella Rossi, Marco Iannetta +5 others
  • 2009
BACKGROUND In recent years, the impact of antituberculous treatment on interferon (IFN)-gamma response to Mycobacterium tuberculosis antigens has been widely investigated, but the results have been controversial. The objective of the present study was: i) to evaluate longitudinal changes of IFN-gamma response to M. tuberculosis-specific antigens in TB(More)
To ascertain whether multiparametric flow cytometry assessment of multifunctional Mycobacterium tuberculosis (Mtb)-specific CD4+ and CD8+ T cells can distinguish between untreated and treated patients with latent tuberculosis infection (LTBI), we enrolled 14 LTBI subjects treated with isoniazid (INH) therapy, 16 untreated LTBI patients, and 25 healthy(More)
  • Katia Monteleone, Carla Selvaggi, Giulia Cacciotti, Francesca Falasca, Ivano Mezzaroma, Gabriella D’Ettorre +4 others
  • 2015
BACKGROUND Several in vitro studies suggested the microRNA-29 (miRNA-29) family is involved in regulating HIV-1 and modulating the expression of interleukin (IL)-32, an anti-HIV-1 cytokine. METHODS To investigate the contribution of the miRNA-29 family to HIV-1 infection in vivo, we compared miRNA-29 expression in PBMC collected from 58 HIV-1-infected(More)
Bulgaria had been free from brucellosis since 1958, but during 2005-2007, a reemergence of human and animal disease was recorded. The reemergence of this zoonosis in the country highlights the importance of maintaining an active surveillance system for infectious diseases that will require full cooperation between public health and veterinary authorities.
  • Miriam Lichtner, Claudio M. Mastroianni, Raffaella Rossi, Gianluca Russo, Valeria Belvisi, Raffaella Marocco +8 others
  • 2011
BACKGROUND Dysregulation of host immune responses plays a critical role in the pathogenesis of severe 2009 pandemic H1N1 infection. Whether H1N1 virus could escape innate immune defense in vivo remains to be investigated. The aim of this study was to evaluate the pattern of innate immune response during human 2009 H1N1 infection. We performed the(More)
BACKGROUND The optimal therapeutic strategies for patients presenting with advanced disease at HIV-1 diagnosis are as yet incompletely defined. METHODS All patients presenting at two outpatient clinics in 2000-2009 with an AIDS-defining clinical condition or a CD4+ T cell count < 200/μL at HIV-1 diagnosis were analyzed for the presence of combined(More)
  • Gabriella d’Ettorre, Giancarlo Ceccarelli, Noemi Giustini, Sara Serafino, Nina Calantone, Gabriella De Girolamo +8 others
  • 2015
BACKGROUND HIV infection results in damage to the gastrointestinal (GI) tract, microbial translocation and immune activation. These are not completely normalized with combined antiretroviral therapy (cART). Moreover, increate morbidity and mortality of cART-treated HIV-infected individuals is associated with inflammation. METHODS In order to enhance GI(More)