Vincenzo Lagani

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The European STREP project HEARTFAID aims at defining an innovative platform of services able to intelligently support clinical operators in the daily management of heart failure patients. The core of the platform intelligence is a Clinical Decision Support System, developed by integrating innovative knowledge representation techniques and hybrid reasoning(More)
In this paper we address the problem of incorporating prior knowledge, in the form of causal relations, in causal models. Prior approaches mostly consider knowledge about the presence or absence of edges in the model. We use the formalism of Maximal Ancestral Graphs (MAGs) and adapt cSAT+ to solve this problem, an algorithm for reasoning with datasets(More)
We present methods able to predict the presence and strength of conditional and unconditional dependencies (correlations) between two variables Y and Z never jointly measured on the same samples, based on multiple data sets measuring a set of common variables. The algorithms are specializations of prior work on learning causal structures from overlapping(More)
In a typical supervised data analysis task, one needs to perform the following two tasks: (a) select the best combination of learning methods (e.g., for variable selection and classifier) and tune their hyper-parameters (e.g., K in K-NN), also called model selection, and (b) provide an estimate of the performance of the final, reported model. Combining the(More)
BACKGROUND Recent technological advances in DNA sequencing and genotyping have led to the accumulation of a remarkable quantity of data on genetic polymorphisms. However, the development of new statistical and computational tools for effective processing of these data has not been equally as fast. In particular, Machine Learning literature is limited to(More)
Biomarker signature identification in "omics" data is a complex challenge that requires specialized feature selection algorithms. The objective of these algorithms is to select the smallest set(s) of molecular quantities that are able to predict a given outcome (target) with maximal predictive performance. This task is even more challenging when the outcome(More)