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Conversation between apoptosis and autophagy: “Is it your turn or mine?”
Drug resistance of cancer cells is often correlated with apoptosis evasion; however, an active involvement of autophagy in this scenario has been recently proposed, based on the evidence thatExpand
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Characterization of stress response in human retinal epithelial cells
The pathogenesis of age‐related macular degeneration (AMD) involves demise of the retinal pigment epithelium and death of photoreceptors. In this article, we investigated the response of human adultExpand
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New arylthioindoles and related bioisosteres at the sulfur bridging group. 4. Synthesis, tubulin polymerization, cell growth inhibition, and molecular modeling studies.
New arylthioindoles along with the corresponding ketone and methylene compounds were potent tubulin assembly inhibitors. As growth inhibitors of MCF-7 cells, sulfur derivatives were superior orExpand
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Mitochondrial fusion: a mechanism of cisplatin-induced resistance in neuroblastoma cells?
Cisplatin induces apoptosis through different pathways. The intrinsic apoptotic pathway is mediated by mitochondria, which, as a result of cisplatin treatment, undergo morphological alterations. TheExpand
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Multiple effects of the Na+/H+ antiporter inhibitor HMA on cancer cells
Amiloride derivatives are a class of new promising chemotherapeutic agents. A representative member of this family is the sodium–hydrogen antiporter inhibitor HMA (5-(N,N-hexamethylene amiloride),Expand
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Study of the effects of a new pyrazolecarboxamide: changes in mitochondria and induction of apoptosis.
Drug resistance of cancer cells is often correlated with the evasion of apoptosis, thus a major goal in cancer research is to search for compounds able to counteract cancer by promoting apoptosis. AExpand
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Poly(ADP-Ribosylation): Beneficial Effects of Its Inhibition
Poly(ADP-ribosylation) is a post-translational modification of proteins which plays a crucial role in basic cellular processes, including DNA repair and replication, transcription and cell death. TheExpand
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Autophagy and Cancer
Autophagy is a housekeeping survival mechanism with a protective function against stress conditions. However, when stress severity or duration increases, it may promote cell death. Paradoxically,Expand
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  • Open Access
From “Click” to “Fenton” chemistry for 5‐bromo‐2′‐deoxyuridine determination
Ascorbic acid (AA) and copper have been increasingly employed in flow cytometry (FCM) and high content analysis (HCA) since the introduction of “click chemistry” as a non‐destructive alternative toExpand
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