Vincenzo Alterio

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Carbonic anhydrases (CAs, EC 4.2.1.1) are metalloenzymes which are ubiquitous in nature and are found in a variety of organisms. In mammals at least 16 different isozymes of CAs have been found. CAs catalyze the reversible hydration of carbon dioxide to bicarbonate with the release of protons. Abnormal levels and/or activities of these enzymes have been(More)
The Carbon Concentration Mechanism (CCM) allows phytoplakton species to accumulate the dissolved inorganic carbon (DIC) necessary for an efficient photosynthesis even under carbon dioxide limitation. In this mechanism of primary importance for diatoms, a key role is played by carbonic anhydrase (CA) enzymes which catalyze the reversible hydration of CO2,(More)
Carbonic anhydrases are ubiquitous metallo-enzymes which catalyze the reversible hydration of carbon dioxide in bicarbonate ions and protons. Recent years have seen an increasing interest in the utilization of these enzymes in CO2 capture and storage processes. However, since this use is greatly limited by the harsh conditions required in these processes,(More)
A new series of compounds containing a sulfamide moiety as zinc-binding group (ZBG) has been synthesized and tested for determining inhibitory properties against four human carbonic anhydrase (hCA) isoforms, namely, CAs I, II, IX, and XII. The X-ray structure of the cytosolic dominant isoform hCA II in complex with the best inhibitor of the series has also(More)
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