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Nonlinear Dynamic Causal Modelling (DCM) for fMRI provides computational modelling of gating mechanisms at the neuronal population level. It allows for estimations of connection strengths with nonlinear modulation within task-dependent networks. This paper presents an application of nonlinear DCM in subjects at high familial risk of schizophrenia performing(More)
UNLABELLED Why are some people strongly motivated by intense sensory experiences? Here we investigated how people encode the value of an intense sensory experience compared with economic reward, and how this varies according to stimulation-seeking preference. Specifically, we used a novel behavioral task in combination with computational modeling to derive(More)
Reinforcement learning theory powerfully characterizes how we learn to benefit ourselves. In this theory, prediction errors-the difference between a predicted and actual outcome of a choice-drive learning. However, we do not operate in a social vacuum. To behave prosocially we must learn the consequences of our actions for other people. Empathy, the ability(More)
Studying the effects of experimentally induced anxiety in healthy volunteers may increase our understanding of the mechanisms underpinning anxiety disorders. Experimentally induced stress (via threat of unpredictable shock) improves accuracy at withholding a response on the sustained attention to response task (SART), and in separate studies improves(More)
Vision is a sense that humans and most animals rely the most onto. Although this sense seems pretty trivial, the visual stimulus is composed of many different dimensions which makes it very complex to decompose, analyze and understand. Scientists state that roughly half of our brain is used for vision processing, it is therefore a very interesting and(More)
Evidence for endemically low statistical power has recently cast neuroscience findings into doubt. If low statistical power plagues neuroscience, this reduces confidence in reported effects. However, if statistical power is not uniformly low, such blanket mistrust might not be warranted. Here, we provide a different perspective on this issue, analysing data(More)
The lateral habenula plays a central role in reward and punishment processing and has been suggested to drive the cardinal symptom of anhedonia in depression. This hypothesis is largely based on observations of habenula hypermetabolism in animal models of depression, but the activity of habenula and its relationship with clinical symptoms in patients with(More)
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