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Although poor decision-making is a hallmark of psychiatric conditions such as attention deficit/hyperactivity disorder, pathological gambling or substance abuse, a fraction of healthy individuals exhibit similar poor decision-making performances in everyday life and specific laboratory tasks such as the Iowa Gambling Task. These particular individuals may(More)
Nonlinear Dynamic Causal Modelling (DCM) for fMRI provides computational modelling of gating mechanisms at the neuronal population level. It allows for estimations of connection strengths with nonlinear modulation within task-dependent networks. This paper presents an application of nonlinear DCM in subjects at high familial risk of schizophrenia performing(More)
Reinforcement learning theory powerfully characterizes how we learn to benefit ourselves. In this theory, prediction errors-the difference between a predicted and actual outcome of a choice-drive learning. However, we do not operate in a social vacuum. To behave prosocially we must learn the consequences of our actions for other people. Empathy, the ability(More)
Deficits in decision-making have been repeatedly observed in various psychiatric disorders (i.e. ADHD, Pathological Gambling, Mania, OCD and Substance Abuse) as well as in frontal lobe patients. Such decision-making deficits are often assessed using the Iowa Gambling task (IGT) [1]. The IGT represents a realistic decision-making task where subjects are(More)
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