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  • Dorota Żółkowska, Raka Jain, +5 authors Michael Heinrich Baumann
  • Chemistry, Medicine
  • Journal of Pharmacology and Experimental…
  • 2009 (First Publication: 1 May 2009)
  • Modafinil is prescribed for numerous medical conditions, but the drug's mechanism of action is unclear. Here, we examined the interaction of modafinil with receptors and transporters in vitro andContinue Reading
  • Vincent Setola, Sandra J. Hufeisen, +5 authors Bryan L. Roth
  • Medicine, Biology
  • Molecular pharmacology
  • 2003 (First Publication: 1 June 2003)
  • Recent findings have implicated the 5-hydroxytryptamine 2B (5-HT2B) serotonin receptor in mediating the heart valve fibroplasia [valvular heart disease (VHD)] and primary pulmonary hypertensionContinue Reading
  • John A. Allen, Julianne M. Yost, +16 authors Jian Jin
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 2011 (First Publication: 24 October 2011)
  • Elucidating the key signal transduction pathways essential for both antipsychotic efficacy and side-effect profiles is essential for developing safer and more effective therapies. Recent work hasContinue Reading
  • Bryan L. Roth, Simon Gibbons, +4 authors Les Iversen
  • Medicine, Chemistry
  • PloS one
  • 2013 (First Publication: 19 March 2013)
  • In this paper we determined the pharmacological profiles of novel ketamine and phencyclidine analogues currently used as 'designer drugs' and compared them to the parent substances via the resourcesContinue Reading
  • Stéphane Doly, Emmanuel Valjent, +4 authors Luc Maroteaux
  • Biology, Medicine
  • The Journal of Neuroscience
  • 2008 (First Publication: 12 March 2008)
  • The “club drug” 3,4-methylenedioxymethamphetamine (MDMA; also known as ecstasy) binds preferentially to and reverses the activity of the serotonin transporter, causing release of serotoninContinue Reading