Learn More
Several large population-based or clinical trial studies have suggested that certain dihydropyridine (DHP) L-type calcium channel blockers (CCBs) used for the treatment of hypertension may confer protection against the development of Alzheimer disease (AD). However, other studies with drugs of the same class have shown no beneficial clinical effects. To(More)
Key pathological processes in Alzheimer's disease (AD) include the accumulation of amyloid beta peptide (Abeta) which, in excess, triggers pathological cascades including widespread inflammation, partly reflected by chronic microglial activation. It has previously been suggested that CD40/CD40L interaction promotes AD like pathology in transgenic mice.(More)
This paper reports on the design and soundness proof, using the Coq proof assistant, of Verasco, a static analyzer based on abstract interpretation for most of the ISO C 1999 language (excluding recursion and dynamic allocation). Verasco establishes the absence of run-time errors in the analyzed programs. It enjoys a modular architecture that supports the(More)
BACKGROUND Abeta deposits represent a neuropathological hallmark of Alzheimer's disease (AD). Both soluble and insoluble Abeta species are considered to be responsible for initiating the pathological cascade that eventually leads to AD. Therefore, the identification of therapeutic approaches that can lower Abeta production or accumulation remains a(More)
Beta-amyloid peptides (Abeta) are the major constituents of senile plaques and cerebrovascular deposits in the brains of Alzheimer's disease patients. We have shown previously that soluble forms of Abeta are anti-angiogenic both in vitro and in vivo. However, the mechanism of the anti-angiogenic activity of Abeta peptides is unclear. In this study, we(More)
Static analyzers based on abstract interpretation are complex pieces of software implementing delicate algorithms. Even if static analysis techniques are well understood, their implementation on real languages is still error-prone. This paper presents a formal verification using the Coq proof assistant: a formalization of a value analysis (based on abstract(More)
Recent advances in verification have made it possible to envision trusted implementations of real-world languages. Java with its type-safety and fully specified semantics would appear to be an ideal candidate; yet, the complexity of the translation steps used in production virtual machines have made it a challenging target for verifying compiler technology.(More)
Background: Ab deposits represent a neuropathological hallmark of Alzheimer's disease (AD). Both soluble and insoluble Ab species are considered to be responsible for initiating the pathological cascade that eventually leads to AD. Therefore, the identification of therapeutic approaches that can lower Ab production or accumulation remains a priority. NFB(More)
Cerebral amyloid angiopathy is a common pathological feature of patients with Alzheimer's disease (AD) and it is also the hallmark of individuals with a rare autosomal dominant disorder known as hereditary cerebral hemorrhage with amyloidosis-Dutch type. We have shown previously that wild type A(beta) peptides are anti-angiogenic both in vitro and in vivo(More)
We have previously shown that transgenic mice carrying a mutant human APP but deficient in CD40L, display a decrease in astrocytosis and microgliosis associated with a lower amount of deposited Abeta. Furthermore, an anti-CD40L treatment causes a diminution of Abeta pathology in the brain and an improved performance in several cognitive tasks in the double(More)