Vincent Gras

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PURPOSE Quantitative water content mapping in vivo using MRI is a very valuable technique to detect, monitor and understand diseases of the brain. At 1.5 T, this technology has already been successfully used, but it has only recently been applied at 3T because of significantly increased RF field inhomogeneity at the higher field strength. To validate the(More)
PURPOSE Estimating tissue water content using high field MRI, such as 3 Tesla (T), is challenging due to the difficulty in dissociating the radio frequency inhomogeneity pattern from the signal arising from tissue intrinsic proton density (PD) variations. To overcome this problem the longitudinal relaxation time T1 can be combined with an initial guess of(More)
PURPOSE A calibration-free parallel transmission method is investigated to mitigate the radiofrequency (RF) field inhomogeneity problem in brain imaging at 7 Tesla (T). THEORY AND METHODS Six volunteers were scanned to build a representative database of RF and static field maps at 7T. Small-tip-angle and inversion pulses were designed with joint kT(More)
The ongoing 1000 brains study (1000BRAINS) is an epidemiological and neuroscientific investigation of structural and functional variability in the human brain during aging. The two recruitment sources are the 10-year follow-up cohort of the German Heinz Nixdorf Recall (HNR) Study, and the HNR MultiGeneration Study cohort, which comprises spouses and(More)
In Magnetic Resonance Imaging at ultra-high field, kT-points radiofrequency pulses combined with parallel transmission are a promising technique to mitigate the B1 field inhomogeneity in 3D imaging applications. The optimization of the corresponding k-space trajectory for its slice-selective counterpart, i.e. the spokes method, has been shown in various(More)
PURPOSE Small gradient delays with respect to radiofrequency (RF) events can have disastrous effects on the performance of bipolar spokes RF pulses used in parallel transmission (pTx). In this work, we propose a new method to characterize and correct this delay with sub-µs precision. METHODS By determining experimentally the phase Δφ producing a 0 ° flip(More)
Little information is available on the impact of hemodialysis on cerebral water homeostasis and its distribution in chronic kidney disease. We used a neuropsychological test battery, structural magnetic resonance imaging (MRI) and a novel technique for quantitative measurement of localized water content using 3T MRI to investigate ten hemodialysis patients(More)
PURPOSE To design a general framework for the optimization of an MRI protocol based on the the diffusion-weighted dual-echo steady-state (DW-DESS) sequence, enabling quantitative and simultaneous mapping of proton density (PD), relaxation times T1 and T2 and diffusion coefficient D. METHODS A parameterization of the DW-DESS sequence minimizing the(More)