• Publications
  • Influence
The discriminatory cost of ICD-10-CM transition between clinical specialties: metrics, case study, and mitigating tools
TLDR
We use the science of networks to quantify the discriminatory impact of the ICD-9-CM to I CD-10-CM transition between clinical specialties. Expand
  • 41
  • 3
  • PDF
‘N-of-1-pathways’ unveils personal deregulated mechanisms from a single pair of RNA-Seq samples: towards precision medicine
TLDR
N-of-1-pathways predicts the deregulated pathways of each patient from RNA-Seq of lung adenocarcinoma patients, generating unsupervised clusters of diametric extreme survival phenotypes. Expand
  • 34
  • 2
  • PDF
ASAP: a web-based platform for the analysis and interactive visualization of single-cell RNA-seq data
TLDR
We developed a fully integrated, web‐based platform aimed at the complete analysis of scRNA‐seq data post genome alignment. Expand
  • 50
  • 1
  • PDF
GA-KDE-Bayes: an evolutionary wrapper method based on non-parametric density estimation applied to bioinformatics problems
TLDR
This paper presents an evolutionary wrapper method for feature selection that uses a non-parametric density estimation method and a Bayesian Classifier. Expand
  • 20
  • 1
  • PDF
EM323: a line search based algorithm for solving high-dimensional continuous non-linear optimization problems
TLDR
This paper presents a performance study of a one-dimensional search algorithm for solving general high-dimensional optimization problems. Expand
  • 23
  • 1
  • PDF
Towards a PBMC "virogram assay" for precision medicine: Concordance between ex vivo and in vivo viral infection transcriptomes
TLDR
We established the first evidence that an interpretable dynamic transcriptome metric, conducted as an ex vivo assays for a single subject, has the potential to predict individualized response to infectious disease without the clinical risks otherwise associated to in vivo challenges. Expand
  • 15
  • 1
  • PDF
From Swarm Art Toward Ecosystem Art
TLDR
This paper presents the swarm paradigm in the context of artistic creation, and more particularly explores the interest of enhancing swarm models with dynamics inspired from natural ecosystems. Expand
  • 8
  • 1
  • PDF
ARTS: automated randomization of multiple traits for study design
TLDR
We present ARTS (automated randomization of multiple traits for study design), which aids researchers in study design by automatically optimizing batch assignment for any number of samples, any number traits and any batch size. Expand
  • 3
  • 1
  • PDF
Unidimensional Search for Solving Continuous High-Dimensional Optimization Problems
TLDR
This paper presents a performance study of two versions of a unidimensional search algorithm aimed at solving high-dimensional optimization problems. Expand
  • 25
  • PDF
Dynamic changes of RNA-sequencing expression for precision medicine: N-of-1-pathways Mahalanobis distance within pathways of single subjects predicts breast cancer survival
TLDR
We developed a global framework, N-of-1-pathways, for a mechanistic-anchored approach to single-subject gene expression data analysis. Expand
  • 21
  • PDF