Vincent Duquenne

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In order to develop a genetic study of human laterality, we conducted an exploratory study concerning one aspect of this phenotype: lattice analysis was used to determine whether the structure of manual preference was the same for right- and left-handers. The study highlights the links between two sets - participants and actions - describing binary data, by(More)
Down syndrome occurs every 1/1000 births and is the most frequent genetic cause of mental retardation. The genetic substrate of Down syndrome, an extra chromosome 21, was discovered by Lejeune, half-a-century ago, and the chromosome has been fully sequenced, although the gene(s) implicated in the mental retardation observed with the syndrome are still(More)
Previous studies have demonstrated that classical inbred strains of laboratory mice do not exhibit large genetic distances when simple sequence repeats (SSRs) are used to test for their polymorphisms whereas mice from wild origin exhibit high polymorphisms (more than 90%) for these sequence when compared with classical inbred strains of laboratory mice. The(More)
In general, lattice theory has helped to simplify, unify and generalize many aspects of mathematics, and it has suggested many interesting new problems. In an era of ever-increasing proliferatlon of scientific results, its relative simplicity and unifying influence are certainly healthy and refreshing. (Birkhoff [4, p. I]) Diagrams prove nothing, but bring(More)
BACKGROUND AND STUDY AIMS The aim of this observational study was to perform the first epidemiology study in a primary care patient population with GERD in the Grand Duchy of Luxembourg and to evaluate the added value of the GERD Impact Scale (GIS) patient questionnaire. PATIENTS AND METHODS 152 Patients with symptoms of GERD from 20 study centers were(More)
The Galois Lattice of a binary relation formalizes it as a concept system, dually ordered in "extension" / "intension". All implications between conjunctions of properties holding in it are summarized by a (recursive) canonical basis -all basis having the same cardinality (see [MR #87k:08009]). We report here how these tools structure phenotypes / genotypes(More)
A previous paper assessed a "Molecular Mapping of Twenty-Four Features of Down Syndrome on Chromosome 21" (Delabar et al., 1993), by analyzing the genotypes/phenotypes of patients suffering from partial trisomy. The mapping was defined through implications--each feature was mapped to the conjunction of cytogenetic bands that were shared by all patients(More)