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The goal of this study was to establish the spatial summation properties associated with inferred PC- and MC-pathway mediated psychophysical contrast discrimination. Previous work has established two paradigms that reveal characteristic signatures of these pathways. In the pulse paradigm, a four-square array was pulsed briefly, on a constant background. In(More)
This study investigated two aspects of visual sensitivity to a change in light level. The first experiment examined the time course of sensitivity to a small amplitude 1-s contrast pedestal presented on a 163-td pedestal within a 115-td surround. The largest contrast pedestal was an 8% contrast change that changed the steady pedestal threshold by only 0.03(More)
The current study examined whether and how the Chinese culture rooted median thinking style may affect banner ad viewing and evaluation. Eye tracking performance was recorded as participants viewed banner ads of different information complexity. High median thinking participants were characterized by a flexible perceptual processing style. Their eye(More)
Retinitis pigmentosa (RP) is a devastating form of retinal degeneration, with significant social and professional consequences. Molecular genetic information is invaluable for an accurate clinical diagnosis of RP due to its high genetic and clinical heterogeneity. Using a gene capture panel that covers 163 of the currently known retinal disease genes,(More)
BACKGROUND Leber congenital amaurosis (LCA) and juvenile retinitis pigmentosa (RP) are inherited retinal diseases that cause early onset severe visual impairment. An accurate molecular diagnosis can refine the clinical diagnosis and allow gene specific treatments. METHODS We developed a capture panel that enriches the exonic DNA of 163 known retinal(More)
Acknowledgements I am especially grateful to my advisor and coauthor Boris Bukh, without whom I would not have been able to finish my PhD. I would like to thank Po-Shen Loh, who first introduced extremal combinatorics to me. I would also like to thank other faculty members of math, physics and computer science departments, Schimmerling and Dejan Slepčev,(More)
Bietti's crystalline dystrophy (BCD) is a rare, autosomal recessive retinal degenerative disease associated with mutations in CYP4V2. In this study, we describe the genetic and clinical findings in 19 unrelated BCD patients recruited from five international retinal dystrophy clinics. Patients underwent ophthalmic examinations and were screened for CYP4V2(More)
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