Vince N. Montes

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Insulin resistance in obesity is believed to be propagated by adipose tissue and liver inflammation. HMGB1 is a multifunctional protein that is pro-inflammatory when released from cells. It has been previously demonstrated that anti-HMGB1 antibody reduces atherosclerotic lesion pro-inflammatory cells and progression of atherosclerosis in a mouse model. To(More)
OBJECTIVE Obesity is associated with insulin resistance, chronic low-grade inflammation, and atherosclerosis. Toll-like receptor 4 (TLR4) participates in the cross talk between inflammation and insulin resistance, being activated by both lipopolysaccharide and saturated fatty acids. The present study was undertaken to determine whether TLR4 deficiency has a(More)
In this issue of Diabetes Care Sasongko et al. (1) make the intriguing observation that apolipoprotein (apo)B and apoA-I, and particularly the apoB-toapoA-I ratio, are related to the presence of diabetic retinopathy in a small cohort of type 1 and type 2 diabetic patients. Moreover, this ratio correlated with the retinopathy severity and also was a better(More)
Latent autoimmune diabetes of adults (LADA) is a subset of type 1 diabetes. The disease accounts for;2–12% of all cases of diabetes (1). The pathogenesis of the disease involves autoimmune destruction of the b-cells of the pancreatic islet that produce insulin. There is a cellmediated effect, via islet-reactive T cells (2), and a humoral immune response via(More)
Adipose tissue inflammation and specifically, pro-inflammatory macrophages are believed to contribute to insulin resistance (IR) in obesity in humans and animal models. Recent studies have invoked T cells in the recruitment of pro-inflammatory macrophages and the development of IR. To test the role of the T cell response in adipose tissue of mice fed an(More)
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