Vinayakumar Siragam

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MicroRNAs (miRNAs) are single-stranded regulatory RNAs, frequently expressed as clusters. Previous studies have demonstrated that the six-miRNA cluster miR-17∼92 has important roles in tissue development and cancers. However, the precise role of each miRNA in the cluster is unknown. Here we show that overexpression of miR-17 results in decreased cell(More)
Angiogenesis and invasion are essential processes for solid tumor growth and dissemination. The tumor development process can be dependent on the activation of a series of signaling pathways, including growth factor-activated pathways. MicroRNAs have been shown to be critical for tumorigenesis, but their roles in cancer angiogenesis, invasion and other(More)
MicroRNAs (miRNAs) are short endogenous noncoding RNA molecules (∼ 22 nucleotides) that can regulate gene expression at the post-transcription level. Research interest in the role of miRNAs in lung biology is emerging. MiRNAs have been implicated in a range of processes such as development, homeostasis, and inflammatory diseases in lung tissues and are(More)
introduction over the past few years, microRNAs (miRNAs) have emerged as a prominent class of gene regulators (1). MiRNAs are single-stranded RNA of 18-24 nucleotides in length derived by RNase III-type enzyme cleavage of endogenous transcripts containing local hairpin structures (2, 3). MiRNA are important to cell physiology because of their ability to(More)
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