Vinayak Joshi

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We are reporting the cases of four children with a diagnosis of acquired immune deficiency syndrome (AIDS) who demonstrated a progressive encephalopathy manifested by loss of motor milestones or intellectual abilities, and weakness with pyramidal tract signs. Two patients were ataxic. One child was cortically blind and suffered myoclonic jerks before his(More)
Pretreatment with L-histidine (850 and 1000 mh/kg, i.p.), a precursor of brain histamine, and chlorcyclizine (25 and 50 mg/kg, i.p.), a H1-receptor blocker, failed to modify apomorphine-induced climbing behaviour in mice. In contrast, pretreatment with L-histidine (850 and 1000 mg/kg) was found to antagonise methamphetamine stereotypy while pretreatment(More)
A new series of compounds 2-((1-(4-(4-arylidene-2-methyl-5-oxo-4,5-dihydro-1H-imidazol-1-yl)phenyl)ethylidene)hydrazono)thiazolidin-4-ones (4a–o) have been synthesized under conventional and microwave irradiation method. All compounds were characterized by IR, 1H NMR, 13C NMR and mass spectra. Newly synthesized compounds were screened for their(More)
The rising prevalence of multi-drug resistant Gram-positive, Gram-negative bacteria and fungi continues to provide momentum for search and development of novel active antimicrobial agents against these pathogens. In continuation to this, the present article deals with the synthesis and antimicrobial activity of a novel series of(More)
In an attempt to find new bio-active molecules, a series of mannich bases N,N-dimethyl-1-(7-methyl-2-(aryl)imidazo[1,2-a]pyridin-3-yl)methanamines 4a–l were synthesized by mannich reaction of 7-methyl-2-(aryl)imidazo-[1,2-a]pyridines 3a–l with paraformaldehyde and N,N-dimethyl amine. Compounds 3a–l were prepared from reaction between different substituted(More)
A series of novel compounds N-(4-(2,6-dichloroquinolin-3-yl)-6-(aryl)pyrimidin-2-yl)-2-morpholinoacetamides (5a–l) were synthesized by a series of multistep reactions. Newly synthesized compounds have been characterized by IR, 1H NMR, 13C NMR, and mass spectral data. Antimicrobial screening of title compounds 5a–l was examined against Gram-positive bacteria(More)
A series of 2-(5-(2-chloro-6-methylquinolin-3-yl)-3-(aryl)-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)ones (4a–l) were synthesized and characterized by IR, 1H NMR, 13C NMR, and mass spectra. All the synthesized compounds were tested for their in vitro antimicrobial activity against Escherichia coli (MTCC 443), Pseudomonas aeruginosa (MTCC 1688),(More)
In order to search for new bioactive molecules with significant antimicrobial action, a series of 1,2,4-triazole and naphthalene analogs bearing structurally diverse substituents, N-(3-mercapto-5-(naphthalen-1-yl)-4H-1,2,4-triazol-4-yl)(aryl)amides 3a–l were synthesized in good yield by a multi-step synthetic procedure. Their antimicrobial activity was(More)