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Converging observations from disparate lines of inquiry are beginning to clarify the cause of brain iron dyshomeostasis in sporadic Creutzfeldt-Jakob disease (sCJD), a neurodegenerative condition associated with the conversion of prion protein (PrP(C)), a plasma membrane glycoprotein, from α-helical to a β-sheet rich PrP-scrapie (PrP(Sc)) isoform.(More)
A direct correlation between brain iron and Alzheimer's disease (AD) raises questions regarding the transport of non-transferrin-bound iron (NTBI), a toxic but less researched pool of circulating iron that is likely to increase due to pathological and/or iatrogenic systemic iron overload. Here, we compared the distribution of radiolabeled-NTBI (59Fe-NTBI)(More)
Human immunodeficiency virus-1 (HIV-1) infects about 35 million people worldwide [1]. There is no vaccine in current clinical use. Although available drug treatments are generally effective in controlling infection , they are not curative, can cause significant side effects and are unable to prevent comorbidities such as cardiovascular disease and cancers.(More)
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