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Intracerebral Transplantation of Differentiated Human Embryonic Stem Cells to Hemiparkinsonian Monkeys
To explore stem cell therapy for Parkinson's disease (PD), three adult rhesus monkeys were first rendered hemiparkinsonian by unilateral intracarotid 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridineExpand
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Titer and Product Affect the Distribution of Gene Expression after Intraputaminal Convection-Enhanced Delivery
Background: The efficacy and safety of intracerebral gene therapy for brain disorders like Parkinson's disease depends on the appropriate distribution of gene expression. Objectives: To assessExpand
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Neurotoxin-Induced Catecholaminergic Loss in the Colonic Myenteric Plexus of Rhesus Monkeys.
OBJECTIVE Constipation is a common non-motor symptom of Parkinson's disease (PD). Although pathology of the enteric nervous system (ENS) has been associated with constipation in PD, the contributionExpand
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Real-Time Intraoperative MRI Intracerebral Delivery of Induced Pluripotent Stem Cell-Derived Neurons
Induced pluripotent stem cell (iPSC)-derived neurons represent an opportunity for cell replacement strategies for neurodegenerative disorders such as Parkinson's disease (PD). Improvement in cellExpand
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α-Synuclein Expression Is Preserved in Substantia Nigra GABAergic Fibers of Young and Aged Neurotoxin-Treated Rhesus Monkeys
α-Synuclein (α-syn) is a small presynaptic protein distributed ubiquitously in the central and peripheral nervous system. In normal conditions, α-syn is found in soluble form, while in Parkinson’sExpand
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α-Synuclein Expression is Preserved in Substantia Nigra Gabaergic Fibers of Young and Aged Neurotoxin-Treated Rhesus Monkeys
Background: α-Synuclein (α-syn) is a small presynaptic protein ubiquitously distributed in the central and peripheral nervous system. In normal conditions α-syn is found in soluble form, while inExpand
State Marketing: The Foreign Countries Experience in the Use of the Satisfaction with State Programs Methods
Purpose. The article is aimed at the study of possible prospects for the implementation of effective methods of satisfaction with public services in Russia based on the foreign countries experienceExpand
[18F]FEPPA PET imaging for monitoring CD68-positive microglia/macrophage neuroinflammation in nonhuman primates
The aim of this study was to examine whether the translocator protein 18-kDa (TSPO) PET ligand [18F]FEPPA has the sensitivity for detecting changes in CD68-positive microglial/macrophage activationExpand
TRANSPARENCY AS A PRINCIPLE OF PUBLIC GOVERNMENT UNDER THE CONDITIONS OF APPLYING INFORMATION TECHNOLOGY
Information and communication technologies include unlimited administrative resource, act as a method in the optimization of the system of public governance, and change traditional institutions andExpand