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Prolyl hydroxylation of hypoxible-inducible factor alpha (HIF-alpha) proteins is essential for their recognition by pVHL containing ubiquitin ligase complexes and subsequent degradation in oxygen (O(2))-replete cells. Therefore, HIF prolyl hydroxylase (PHD) enzymatic activity is critical for the regulation of cellular responses to O(2) deprivation(More)
Postnatal day (P)20 rats are sensitive to CA1 injury following a single injection of kainic acid (KA) but are resistant to this injury when animals have a history of two neonatal seizures. We hypothesized that the two earlier seizures led to neuroprotection by a preconditioning mechanism. Therefore, morphology, [Ca(2+)](i) and NMDA subunit proteins of the(More)
Cannabinoids have anti-convulsant effects in both in vivo and in vitro models of status epilepticus. Since the development of spontaneous seizures and neuronal vulnerability are age-dependent, we hypothesized that the anti-convulsant effects of cannabimimetics are also age-dependent. We administered a single injection of varied doses of (R+)WIN 55,212 (0.5,(More)
The existing high technology laser-beam detectors of gravitational waves may find very useful applications in an unexpected area-geophysics. To make possible the detection of weak gravitational waves in the region of high frequencies of astrophysical interest, ∼ 30 − 10 3 Hz, control systems of laser interferometers must permanently monitor, record and(More)
A study was made of the activity of the blood serum proteolytic enzymes in 100 rheumatoid arthritic patients. Their noticeable activation well correlated with clinical types of disease, was revealed. Maximum proteolysis values were noted in parallel with high degrees of activity, seropositivity, systemic signs, rapid progression and multiple articular(More)
The thiospinels of composition FeCr(2)S(4) and Fe(1+x)Cr(2-2x)Sn(x)S(4) with 0<x<0.1 have been examined by means of extended x-ray absorption fine structure, Mössbauer spectroscopy and magnetoresistance techniques. The structural characterization shows that tin enters the spinel-related lattice as Sn(4+) and occupies the octahedral B site. Appreciable(More)