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Overactivation of Fear Systems to Neutral Faces in Schizophrenia
TLDR
Patients with schizophrenia show an increased response of the amygdala to neutral faces, which is sufficient to explain their apparent deficit in amygdala activation to fearful faces compared with neutral faces. Expand
Loss of imagery phenomenology with intact visuo-spatial task performance: A case of ‘blind imagination’
TLDR
The case of a patient, MX, who abruptly lost the ability to generate visual images is described, indicating that successful performance in visual imagery and visual memory tasks can be dissociated from the phenomenal experience of visual imagery. Expand
Functional Magnetic Resonance Imaging (fMRI) reproducibility and variance components across visits and scanning sites with a finger tapping task
TLDR
Results suggest that combined results from multicentre fMRI studies can be confidence in combined results, at least when a consistent protocol is followed on similar machines in all participating scanning sites and care is taken to select homogeneous subject groups. Expand
A visual joke fMRI investigation into Theory of Mind and enhanced risk of schizophrenia
TLDR
This study is the first time relatives of individuals with schizophrenia have been imaged using a ToM paradigm, and the results provide evidence of both a state and state-mediated trait effect. Expand
fMRI changes over time and reproducibility in unmedicated subjects at high genetic risk of schizophrenia
TLDR
The current results suggest that functional changes over time occur in the lateral temporal cortex as high genetic risk subjects become symptomatic, and indicate the usefulness of functional imaging tools for investigating progressive changes associated with state and trait effects in schizophrenia. Expand
Prospective multi-centre Voxel Based Morphometry study employing scanner specific segmentations: Procedure development using CaliBrain structural MRI data
TLDR
The results indicate the development of scanner specific priors for SPM can assist in pooling of scan resources from different research centres, and facilitate improvements in the statistical power of quantitative brain imaging studies. Expand
Spectro-temporal processing during speech perception involves left posterior auditory cortex
TLDR
This functional magnetic resonance imaging study investigates the neural underpinnings of spectro-temporal integration during speech perception by observing an activation increase in the left posterior primary and secondary auditory cortex and Heschl's gyrus and planum temporale encroaching onto the superior temporal sulcus. Expand
An examination of the language construct in NIMH's research domain criteria: Time for reconceptualization!
TLDR
The new models of language with their remarkably multifaceted constructs force a re‐examination of the NIMH RDoC conceptualization of language and thus the neuroscience and genetics underlying this concept. Expand
A review of neuroeconomic gameplay in psychiatric disorders
TLDR
This review summarises findings of neuroeconomic gameplay studies in Axis 1 psychiatric disorders and advocates the use of these games as measures of the RDoC Affiliation and Attachment, Reward Responsiveness, Reward Learning and Reward Valuation constructs. Expand
Correlations between fMRI activation and individual psychotic symptoms in un-medicated subjects at high genetic risk of schizophrenia
TLDR
Results support a role for the lateral temporal cortex in hallucinations and medial temporal lobe in positive psychotic symptoms and highlight the potential role of the cerebellum in the formation of delusions. Expand
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