Viktoria C Ruf

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BACKGROUND Special diphenyl-pyrazole compounds and in particular anle138b were found to reduce the progression of prion and Parkinson's disease in animal models. The therapeutic impact of these compounds was attributed to the modulation of α-synuclein and prion-protein aggregation related to these diseases. METHODS Photophysical and photochemical(More)
While cerebrospinal fluid (CSF) biomarkers for Creutzfeldt-Jakob disease (CJD) are established and partly included in the diagnostic criteria, no blood biomarkers are available. Here, we assessed the utility of serum neurofilament light chain (NF-L) and tau protein in comparison to CSF markers (NF-L and phosphorylated NF heavy chain (pNF-H), tau, S100B,(More)
Am 11. Mai 2012 brachte die Änderung der Approbationsordnung für Ärzte einige Neuerungen in der medizinischen Ausbildung mit sich. Zu den bedeutendsten Änderungen zählen die Abschaffung des im Jahr 2006 erstmals durchgeführten „Hammerexamens“ mit Wiedereinführung des 2. und 3. Staatsexamens, die Möglichkeit, das Praktische Jahr (PJ) in Teilzeit zu(More)
Aggregation of alpha-synuclein (α-SN) is a key pathogenic event in Parkinson's disease (PD) leading to dopaminergic degeneration. The identification of natural compounds inhibiting α-SN aggregation may have a major role in treating PD. Different Scutellaria species are known as valuable medicinal plants, primarily due to their high flavonoid levels.(More)
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