Vikraman Subramani

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Homogeneity Index (HI) is an objective tool to analyz the uniformity of dose distribution in the target volume. Various formulae have been described in literature for its calculation but there is paucity of data regarding the ideal formula and the factors affecting this index. This study was undertaken to analyze HI in our patients using various formulae(More)
The authors report the distribution of acetylcholinesterase activity and catecholamine fluorescence in the intact and completely transected rat spinal cord. The catecholamine terminals were scarce in the posterior horn and abundant in the intermediale and anterior horn regions. In the thoracic region, intense amine fluorescence was seen in the(More)
This report describes qualitative and quantitative studies performed on ten muscle biopsies from chronic uremic patients on renal dialysis at light and electron microscopic (EM) levels. The muscle biopsies showed myopathic changes (variation in fiber size, central nuclei, and fiber splitting). Histochemical studies showed type II fiber atrophy and lipid(More)
In this paper we present sequential morphologic changes produced in rat muscle mitochondria. Respiratory toxins such as crotoxin (rattle-snake venom) and 2,4-dinitrophenol (DNP-an uncoupler of oxidative phosphorylation) were injected in rat quadriceps muscle and the mitochondrial alterations were studied at various time intervals. The series of(More)
This study is aimed to evaluate the impact of static and dynamic intensity modulated radiotherapy (IMRT) delivery techniques planned with Eclipse TPS on the integral dose to the healthy normal tissue surrounding the tumor-bearing area and to the volume receiving doses < 5 Gy in patients with carcinoma nasopharynx treated with Simultaneous Integrated Boost(More)
The intra-arterial injection of 2-4 dinitrophenol, an uncoupler of oxidative phosphorylation, resulted in the production of ragged red fibers. The ultrastructure of these fibers showed intramitochondrial paracrystalline inclusions, laminar and fingerprint bodies. Antimycin A and oligomycin injection (which inhibit mitochondrial respiration) only caused(More)
PURPOSE Interstitial brachytherapy (IBT) is used as an alternative to intracavitary radiotherapy in the management of cervical carcinoma. We have devised a new technique called interstitial brachytherapy guided intensity modulated radiotherapy (IBGIMRT) which can potentially reduce doses to organs at risk (OaRs). It utilizes IMRT planning on the target(More)
The ultrastructural studies have shown three types of motor endings in the macaque intrafusal fibers: 1) unindented axon terminals with smooth or shallowly folded postsynaptic membrane; 2) indented terminals with few postsynaptic folds; and 3) indented terminals with heavily folded postsynaptic membrane. The terminals on bag 1 and chain fibers were(More)
In this study we report on the effect of halothane exposure on the skeletal muscle membrane and calcium localization in 9 patients with confirmed susceptibility to malignant hyperthermia and compare them with 11 non-susceptible cases of malignant hyperthermia. Two normal muscle specimens with physiologically induced muscle contractures were also included(More)
Caffeine contractures were recorded from thin bundles and whole extensor digitorum longus (EDL) and soleus muscles of rat, and correlated with preparation size and fiber types. Thin bundles were more sensitive to caffeine and halothane than whole muscles, and bundles of 100% type I fibers were more sensitive than bundles of 100% type II fibers. Magnitude of(More)