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- Publications
- Influence

Plasma exosomes protect the myocardium from ischemia-reperfusion injury.

- J. Vicencio, D. Yellon, +10 authors S. Davidson
- Medicine
- Journal of the American College of Cardiology
- 21 April 2015

BACKGROUND
Exosomes are nanometer-sized vesicles released from cells into the blood, where they can transmit signals throughout the body. Shown to act on the heart, exosomes' composition and the… Expand

Knockdown of Interleukin-1 Receptor Type-1 on Endothelial Cells Attenuated Stress-Induced Neuroinflammation and Prevented Anxiety-Like Behavior

- E. Wohleb, J. Patterson, Vikram Sharma, N. Quan, J. Godbout, J. Sheridan
- Medicine, Biology
- The Journal of Neuroscience
- 12 February 2014

Interleukin-1β (IL-1β) is an inflammatory cytokine that plays a prominent role in stress-induced behavioral changes. In a model of repeated social defeat (RSD), elevated IL-1β expression in the brain… Expand

Almost tight recursion tree bounds for the Descartes method

- Arno Eigenwillig, Vikram Sharma, C. Yap
- Mathematics, Computer Science
- ISSAC '06
- 9 July 2006

We give a unified ("basis free") framework for the Descartes method for real root isolation of square-free real polynomials. This framework encompasses the usual Descartes' rule of sign method for… Expand

Complexity Analysis of Root Clustering for a Complex Polynomial

- R. Becker, Michael Sagraloff, Vikram Sharma, J. Xu, C. Yap
- Mathematics, Computer Science
- ISSAC '16
- 20 July 2016

Let F(z) be an arbitrary complex polynomial. We introduce the {local root clustering problem}, to compute a set of natural epsilon-clusters of roots of F(z) in some box region B0 in the complex… Expand

A near-optimal subdivision algorithm for complex root isolation based on the Pellet test and Newton iteration

- R. Becker, Michael Sagraloff, Vikram Sharma, C. Yap
- Mathematics, Computer Science
- J. Symb. Comput.
- 21 September 2015

We describe a subdivision algorithm for isolating the complex roots of a polynomial $F\in\mathbb{C}[x]$. Given an oracle that provides approximations of each of the coefficients of $F$ to any… Expand

Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p53

- K. Tikoo, D. N. Tripathi, D. Kabra, Vikram Sharma, A. Gaikwad
- Biology, Medicine
- FEBS letters
- 6 March 2007

Diabetic nephropathy (DN) is one of the main causes of end stage renal disease (ESRD) and a leading cause of diabetes mellitus related morbidity and mortality. Recently, sirtuin are reported to have… Expand

Robust Geometric Computation

- C. Yap, Vikram Sharma
- Computer Science
- Encyclopedia of Algorithms
- 2008

Nonrobustness refers to qualitative or catastrophic failures in geometric algorithms arising from numerical errors. Section 45.1 provides background on these problems. Although nonrobustness is… Expand

Complexity of real root isolation using continued fractions

- Vikram Sharma
- Computer Science, Mathematics
- Theor. Comput. Sci.
- 10 December 2008

In this paper, we provide polynomial bounds on the worst case bit-complexity of two formulations of the continued fraction algorithm. In particular, for a square-free integer polynomial of degree n… Expand

Differential effects of tannic acid on cisplatin induced nephrotoxicity in rats

- K. Tikoo, D. Bhatt, A. Gaikwad, Vikram Sharma, D. Kabra
- Biology, Medicine
- FEBS letters
- 15 May 2007

Cisplatin is a widely used antineoplastic drug. Major drawback of cisplatin therapy is its nephrotoxicity. The objective of this study was to check the effect of tannic acid on cisplatin induced… Expand

Analytic Root Clustering: A Complete Algorithm Using Soft Zero Tests

- C. Yap, Michael Sagraloff, Vikram Sharma
- Computer Science
- CiE
- 1 July 2013

A challenge to current theories of computing in the continua is the proper treatment of the zero test. Such tests are critical for extracting geometric information. Zero tests are expensive and may… Expand