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Clinical evidence suggests a potentially causal interaction between sleep and affective brain function; nearly all mood disorders display co-occurring sleep abnormalities, commonly involving rapid-eye movement (REM) sleep. Building on this clinical evidence, recent neurobiological frameworks have hypothesized a benefit of REM sleep in palliatively(More)
Aging has independently been associated with regional brain atrophy, reduced slow wave activity (SWA) during non-rapid eye movement (NREM) sleep and impaired long-term retention of episodic memories. However, whether the interaction of these factors represents a neuropatholgical pathway associated with cognitive decline in later life remains unknown. We(More)
A hallmark feature of cognitive aging is a decline in the ability to form new memories. Parallel to these cognitive impairments are marked disruptions in sleep physiology. Despite recent evidence in young adults establishing a role for sleep spindles in restoring hippocampal-dependent memory formation, the possibility that disrupted sleep physiology(More)
Executive Summary This report describes a variety of work that uses web-scale N-gram data. This work directly arose from a six-week research workshop at the Center for Language and Speech Processing at Johns Hopkins University in 2009. While the web provides a fantastic linguistic resource, collecting and processing data at web-scale is beyond the reach of(More)
Independent evidence associates β-amyloid pathology with both non-rapid eye movement (NREM) sleep disruption and memory impairment in older adults. However, whether the influence of β-amyloid pathology on hippocampus-dependent memory is, in part, driven by impairments of NREM slow wave activity (SWA) and associated overnight memory consolidation is unknown.(More)
Cognitive decline is a problematic and disabling consequence of aging, with impairments in hippocampus-dependent memory being one of the most debilitating symptoms 1–4. The accumulation of cortical B-amyloid (AB) and subcortical tau proteins are leading candidate mechanisms underlying hippocampus-dependent memory impairment in aging and Alzheimer's disease(More)
Stimulant use is a significant and prevalent problem, particularly in criminal populations. Previous studies found that cocaine and methamphetamine use is related to impairment in identifying emotions and empathy. Stimulant users also have abnormal neural structure and function of the ventromedial prefrontal cortex (vmPFC), amygdala, and anterior (ACC) and(More)