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The CTFA Evaluation of Alternatives Program is an evaluation of the relationship between data from the Draize primary eye irritation test and comparable data from a selection of promising in vitro eye irritation tests. In Phase III, data from the Draize test and 41 in vitro endpoints on 25 representative surfactant-based personal care formulations were(More)
Hydrodynamic studies on monomer chromatin subunits (v1) as a function of ionic strength (0.7 mM to 100 mM KCl) indicate two salt-dependent conformational transitions. An abrupt transition occurs at about 7.5 mM ionic strength. Decreasing the ionic strength from 10 to 5 mM results in a decrease in s20,w of the v1 from 11.1 to 9.9 S. The diffusion coefficient(More)
Three variations of an in vitro assay system called EYTEX were evaluated by comparing maximum in vivo Draize scores for 70 experimental consumer product formulations. The EYTEX in vitro assay (EIA) was chosen for in-house evaluation because it is an economical, objective system that is easy to learn. In the present study, double-blind samples were tested at(More)
Target biomacromolecular assay systems utilize as endpoints quantifiable alterations in key macromolecules elicited by various chemicals and formulations. The EYTEX Assay System, an example of a target biomacromolecular test method, has been used to predict the in vivo ocular irritancy potential of chemicals and formulations. The biomacromolecular reagent(More)
The relative validity of three self-report measures of assertiveness was assessed by correlating the scored obtained by 88 student nurses with peer and faculty ratings of assertiveness. Self-reported assertiveness failed to predict frequency of class participation within a subsample of 48 students. Type of instructional setting, however, did exert a(More)
Hydrodynamic, spectroscopic, and chemical crosslinking studies on monomer chromatin subnits are reported as a function of ionic strength, pH, and temperature. In earlier studies, two salt-dependent conformational transitions were described (Gordon et al., Proceedings of the National Academy of Science, 75, 660, 1978). Transition one occurred between 0.7 and(More)