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OBJECTIVES To design and validate a condition-specific quality of life questionnaire for the assessment of women with urinary incontinence, and to use the questionnaire to assess the quality of life of women with specific urodynamic diagnoses. SETTING A tertiary referral urogynaecology unit at King's College Hospital, London. DESIGN The questionnaire(More)
CONTEXT Antimuscarinic agents are currently the first-line pharmacotherapy for overactive bladder. OBJECTIVES A systematic review published in 2005 was updated, including data on a newly licensed antimuscarinic (fesoterodine). The primary aim of this study was to systematically review evidence on the efficacy of licensed administration of antimuscarinic(More)
To develop a simple, valid, reliable questionnaire to assess the severity of symptoms and their impact on the quality of life in women with urogenital prolapse. Women recruited from gynaecology outpatient clinics were asked to complete a prolapse quality of life questionnaire (P-QOL) before their hospital visit. At the time of the visit, they were examined(More)
OBJECTIVE The aims of this study were to determine the medium-term subjective outcome of treatment for women with a urodynamic diagnosis of detrusor instability and low bladder compliance. SETTING A tertiary referral urogynaecology clinic. PARTICIPANTS AND METHODS One thousand one hundred and five women referred for the investigation of their urinary(More)
BACKGROUND Overactive bladder (OAB) syndrome with urinary incontinence (UI) is prevalent in the population and impairs health-related quality of life (HRQOL). OBJECTIVE To assess the impact on efficacy, safety, and HRQOL of onabotulinumtoxinA (BOTOX(®), Allergan, Inc.) treatment in patients with OAB with UI. DESIGN, SETTING, AND PARTICIPANTS This(More)
BACKGROUND Mirabegron, a β(3)-adrenoceptor agonist, has been developed for the treatment of overactive bladder (OAB). OBJECTIVE To assess the efficacy and tolerability of mirabegron versus placebo. DESIGN, SETTING, AND PARTICIPANTS Multicenter randomised double-blind, parallel-group placebo- and tolterodine-controlled phase 3 trial conducted in 27(More)
OBJECTIVE To assess the relationship and location of vaginal prolapse severity to symptoms and quality of life. DESIGN A prospective observational study. SETTING Urogynaecology Unit, Imperial College, St Mary's Hospital, London. POPULATION Women with and without symptoms of vaginal prolapse. METHODS All women completed a validated Prolapse Quality(More)
OBJECTIVE To determine whether transvaginal ultrasound measurement of bladder wall thickness can be used as a screening test for detrusor instability in women with urinary symptoms. DESIGN A blinded prospective study. SETTING A London teaching hospital. PARTICIPANTS One hundred and eight-four symptomatic women presenting to a urodynamic clinic. MAIN(More)
OBJECTIVE To validate the italian translated version of the prolapse quality of life questionnaire (P-QOL). STUDY DESIGN The P-QOL questionnaire was translated into Italian and administered to women recruited from a gynaecology outpatient clinic. All women completed a P-QOL questionnaire at the time of the visit, and were examined in left lateral position(More)