Vijayaphanikumar Yemparala

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Thiazolyl cyclic peptide antibiotics are known for their poor aqueous solubility and unfavorable pharmacokinetics (PK) and hence pose challenging tasks in developing these antibiotics as clinical candidates. In the current paper, we report a possible way to address these challenges with exemplification of our antibiotic PM181104. The approach was to prepare(More)
Thiazolyl peptide antibiotics are highly modified cysteine-containing macrocyclic peptides with several distinctive common features such as the presence of thiazole rings, dehydro amino acids and a highly substituted pyridine centerpiece at the junction of the macrocyclic ring. They are known for their potent in vitro antibacterial activity against a wide(More)
Drug resistance has become a global threat that, if not addressed, may return us to the preantibiotic era. A way to overcome the problem of growing incidence of global antibiotic resistance is to introduce compounds belonging to classes that are new to the clinic. During a screening of the marine microbial extract library for new antibiotics, one of the(More)
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