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—Recent studies have suggested a potentially important role for a family of tiny regulatory RNAs, known as microRNAs (miRNAs or miRs), in the control of diverse aspects of cardiac function in health and disease. Although the field of miRNA biology is relatively new, there is emerging evidence that miRNAs may play an important role in the pathogenesis of… (More)
BACKGROUND Tumor necrosis factor superfamily ligands provoke a dilated cardiac phenotype signal through a common scaffolding protein termed tumor necrosis factor receptor-associated factor 2 (TRAF2); however, virtually nothing is known about TRAF2 signaling in the adult mammalian heart. METHODS AND RESULTS We generated multiple founder lines of mice with… (More)
Unsupervised K-means cluster analysis and self-organizing maps (SOM) were employed to cluster patients based on feature values in the large Digitalis Investigation Group (DIG) trial database of digoxin for heart failure treatment. We observed that use of standardized features for input into SOM resulted in clusters for which the pattern of features were… (More)
We studied heart failure mortality and hospitalization of N=7,788 subjects in the Digitalis Intervention Group (DIG) clinical trial. Cases were defined as subjects with New York Heart Association (NYHA) class III–IV symptoms, while controls were defined as subjects with NYHA class I–II symptomatology. Controls were propensity matched with… (More)
Hepcidin does not mediate anemia in chronic heart failure patients, and is suppressed in chronic heart failure. Abstract The Role of Valsartan and Carvedilol in Patients with Chemotherapy Associated Cardiomyopathy Who Are Intolerant to Angiotensin Converting Enzyme Inhibitors.