Vijay C. Swamy

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Calcium utilization by smooth muscle is briefly reviewed. A variety of stimulant-evoked calcium mobilization processes exist including utilization of intracellular Ca2+ and translocation of Ca2+ through voltage-sensitive and insensitive channels. The extent of use of these several sources is both stimulant and tissue-dependent and it is probable that most(More)
15.Pharmacological Management of Chronic Heart Failure 151 Mitchell S. Finkel and Humayan Mirza 16.Antiarrhythmic Drugs 160 Peter S. Fischbach and Benedict R. Lucchesi 17.Antianginal Drugs 196 Garrett J. Gross 18.The Renin–Angiotensin–Aldosterone System and Other Vasoactive Substances 206 Lisa A. Cassis 19.Calcium Channel Blockers 218 Vijay C. Swamy and(More)
BAY K 8644 (methyl-1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl) pyridine-5-carboxylate) and CGP 28 392 (ethyl-4(2-difluoromethoxyphenyl)-1,4,5,7-tetrahydro-2-methyl-5-++ +oxofuro- [3,4-b]pyridine-3-carboxylate) are closely related in structure to nifedipine and other 1,4-dihydropyridine Ca2+ channel antagonists. However, both BAY K 8644 and(More)
The effect of depletion of extracellular Ca2+ (Ca2+ext) on the loss of responsiveness of the guinea pig ileal longitudinal muscle (g.p.i.l.m.) and the rat vas deferens (r.v.d.) to K+ and cis-2-methyl-4-dimethylaminomethyl-1,3-dioxolane methiodide (CD), and K+ and noradrenaline (NA), has been examined and compared with the effects of a variety of local(More)
Comparison was made of the inhibition by D 600 of the norepinephrine (NE)- and clonidine-induced responses of aortic strips from normotensive (WKY) and spontaneously hypertensive rats (SHR). Clonidine-induced responses of aortae from both strains of rats were markedly more susceptible to inhibition by D 600 than those of NE. Omission of calcium from the(More)
Postsynaptic alpha-adrenoceptors in the rat tail artery have been examined by determining the pA2 values for antagonists against several alpha-adrenoceptor agonists. In this tissue the alpha-adrenoceptor agonists all produce concentration-dependent mechanical responses with the following rank order of potency: clonidine greater than norepinephrine greater(More)
The cation ionophore X-537A in the concentration range of 10(-6) to 3 X 10(-5) M produced contractions in the rat and guinea-pig vas deferens. No contractile effect was produced in either of the vasa deferentia preparations by the ionophore A-23187 in the concentration range of 10(-7) to 5 X 10(-5) M. In contrast, X-537A had no contractile effect on the(More)