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The pharmacokinetic parameters of cladribine (CdA) in patient plasma and its intracellular nucleotides CdA 5’monophosphate (CdAMP) and CdA 5’-triphosphate (CdATP) were delineated in circulating(More)
2-Chloro-2′-deoxyadenosine (CdA, Cladribine), is a purine antimetabolite currently under investigation in phase II clinical trials for the treatment of lymphoid malignancies. Significant differences(More)
1. Cytotoxic synergism of drugs cis-diamminedichloroplatinum(II) (cis-DDP) and arabinosylcytosine (araC) was studied both on the level of interaction with DNA in chemically determined conditions and(More)
The pharmacokinetic parameters of cladribine (CdA) in patient plasma and its intracellular nucleotides CdA 5’monophosphate (CdAMP) and CdA 5’-triphosphate (CdATP) were delineated in circulating(More)