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Based on new advancements in digital technology, we developed a PC- and DSP-based measurement and control system for isolated papillary muscle experiments. High flexibility was obtained through a three level control. Length or force was controlled real-time with a sample frequency of 5000 Hz. Muscle length and up to three segment lengths were measured(More)
In the intact heart, there are simultaneous changes in stress and length throughout the cardiac cycle. In a recently developed digital control system for experiments on isolated papillary muscles from rabbit right ventricle, we included a controlled auxotonic twitch. This twitch allowed proportional changes in stress and length, as if the muscle was acting(More)
Mathematical models have been used to represent the cardiac muscle function or some of its underlying mechanisms. The models range from simple force-velocity relations to complex models of calcium handling and cross-bridge kinetics. Typically, a model is developed to validate hypotheses that have evolved from some experimental findings. However,(More)
The mechanical dynamics of cardiac muscles are expressed as changes in muscle length and force. In isolated muscle, the length and force dynamics have been studied separately. Under auxotonic loading conditions, however, there are simultaneous changes in length and force. We wanted to study the differences in mechanical dynamics in twitches with different(More)
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