Victoria V. Libina

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Paracetamolum (PC) after i.p. administration to rats at the therapeutic (100.0 mg/kg) and subtoxic (500.0 mg/kg) doses was shown to induce significant and dose-dependent elevation of the level of malone dialdehyde (MDA) as well as the increase in a certain extent of chemiluminescence (CL) being injected at the higher dose. Acetylsalicylic acid (ASA) at the(More)
A rapid, precise, accurate, and selective highperformance liquid chromatographic method with fluorescence detection has been validated and used for analysis of amisulpride in human plasma after a simple solid-phase extraction procedure. Compounds were separated on a CN column with 0.03 M potassium dihydrogen phosphate (pH 6.5)–acetonitrile 65:35 (v/v) as(More)
Lysine acetylsalicylate, a water-soluble salt of acetylsalicylic acid, administered intravenously to rabbits (15 and 100 mg/kg) and also in vitro (2-10 mg/ml) produced antiaggregational and anticoagulant effects pertaining to acetylsalicylic acid. Pharmacokinetics of acetylsalicylic acid injected intravenously to rabbits in the form of lysine(More)
The analgesic effect, acute toxicity and pharmacokinetics of lysine acetylsalicylate (LAS), a water-soluble salt of acetylsalicylic acid (ASA) were studied as compared with a 50% solution of analgin and a 4% solution of amidopyrine at intramuscular administration and ASA administered intragastrically. During inflammation-induced pain in rats LAS exerts a(More)
Effects of amidopyrine, phenacetin and paracetamol on the viability and energetic state of isolated rat hepatocytes were compared. During incubation in minimal salt solution all drugs in concentrations above 1 mM in dose-dependent manner decreased the viability of hepatocyte suspension assessed by trypan blue dye inclusion and inhibited the ATP synthesis(More)
i. N. Maggi, C. R. Pasqualucci, R. Ballotta, et al., Chemotherapia (Basel), ii, 285 (1966). 2. P. Sensi, N. Maggi, and R. Ballotta, J. Med. Chem., ~, 596-602 (1964). 3. M.D. Mmshkovskii, Drugs [in Russian], 8th edn., Moscow (1977), Vols. 1-2. 4. M, Negwer, Organisch-Chemische Arzneimittel ~nd ihke Synonyma, Berlin (1978), Vols. 1-3. 5. J. Garcia-Rafanell et(More)
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