Learn More
Genes that encode killer Ig-like receptors (KIRs) and their HLA class I ligands segregate independently; thus, some individuals may express an inhibitory KIR gene but not its cognate ligand. We hypothesised that these patients with KIR-HLA receptor-ligand mismatch have a low risk of relapse after an autologous haematopoietic stem cell transplantation (HCT).(More)
Graft-versus-host disease (GVHD) is a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). To identify recipient risk factors, a genome-wide study was performed including 481,820 single-nucleotide polymorphisms (SNPs). Two GVHD susceptibility loci (rs17114803 and rs17114808) within the SUFU gene were(More)
Sir, We agree with Stern et al that missing KIR-ligand does not imply inhibitory KIR – HLA receptor – ligand mismatch. In fact, 2 out of our 16 patients (13%) would have been misclassified using the analytic approach of Stern et al (one for KIR3DL1 – Bw6/6 and the other for KIR2DL1 – HLA-C Asn80/Asn80). The statistical implication for misclassification and(More)
  • 1